steady state takes weeks
#semaglutide 2026-01-18
Sunday52 messages11 participantstimes are UTC
Highlights from this day
- fake_tracking — is the plateau at 5 weeks normal or am i doing something wrong 14:04
- fake_tracking — sorry to jump in back after 17 months off, do i restart at 0.25 or somewhere higher 14:18
- customs_owl — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 14:20
- half_life_hal — lost about 14kg on the low doses before i even got to 1, which surprised me, thats just me 14:55
- deadspace — the appetite effect faded for me around 5 months and going up fixed it for a while 15:38
held at 5 and lost 100lb over 22 months, slower than the trials and fine by me, thats just me
mine faded too
my 30 vial in 0.5ml gives 8mg/ml so 2.4 lands on 40 units, thats why i picked that volume
the long half life flattens the trough more than people expect, i never felt a day seven dip
vials not pens here
sorry to jump in my Janoshik report on the GL Biochem vial came back 99 against a certificate saying 97.4
slower worked better
how long till steady state, ive read the half life is about a week
is the plateau at 5 weeks normal or am i doing something wrong
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
sorry to jump in back after 17 months off, do i restart at 0.25 or somewhere higher
🧊6❤️10
does the seven day half life mean the last two days are weaker
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
❤️1✅8🧊17
did anyone titrate slower than four weeks a step and how did that go
my dose day drifted from friday to sunday, does that reset anything
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ymmv
is 2.4 the top or do people go past it
restarted after 17 months off at a low dose and the nausea arrived exactly like the first time
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
lost about 14kg on the low doses before i even got to 1, which surprised me, thats just me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
how long did the first 14kg take for people at the low doses
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, n of 1 obviously
ok so does moving my dose day by two days matter with a seven day half life
dose day is sunday for me only because thats when i remember, not because sunday matters, i have it written down somewhere
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
the appetite effect faded for me around 5 months and going up fixed it for a while
📉7👍7📈1
plateaus move
went too fast once
STEP 1 ran to 68 weeks. thats the one everyone half remembers
vial units and pen clicks are different systems, mixing the two is how people end up wrong
is the plateau usually appetite coming back or just the scale stopping
right so did anybody find a difference between CPC and pharmacy at the same 0.5
ok so $185 a month for compounded against what brand costs locally is why most people here use vials, i think
held there too
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
*VendorInvestigate not the other one
seven days ish
half life is about a week so youre roughly four to five weeks to steady state on any new dose
the plateau hit me at 14 weeks and moved again about a month later without a dose change, i have it written down somewhere
🙏1📉1🧪2
whats the actual licensed ceiling, i keep seeing different numbers
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
give it four weeks
quick one i held at 2 for 8 months and it was the best decision i made
is there a reason to hold at 1.7 rather than going to 2.4
Reminder for travel_cooler: dose day is today. Set 8 days ago.
im 9 months in at 2 and the appetite effect faded, is that a thing
right so i stayed on 1.7 for 6 months and never went to 2.4, appetite was already where i needed it
did the STEP 4 withdrawal arm show what i think it showed
*Janoshik not the other one