slower worked better
#semaglutide 2026-01-03
Saturday51 messages9 participantstimes are UTC
Highlights from this day
- ten_of_ten — 20 months at 2.4 and the honest summary is diminishing returns after the first half 14:08
- cold_chain_cmdr — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 14:31
- nordic_price_nils — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 14:51
- ten_of_ten — my Medutest report on the GGPeps vial came back 96.8 against a certificate saying 99.2 17:06
- mag_citrate — brand vs compounded, is there a difference people can actually feel 17:25
20 months at 2.4 and the honest summary is diminishing returns after the first half
👍7🤝7
*Janoshik not the other one
£185 a month for compounded against what brand costs locally is why most people here use vials
lost about 26kg on the low doses before i even got to 1, which surprised me
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
[edited]is there a reason to hold at 1.7 rather than going to 2.4
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
cold_chain_cmdr£185 a month for compounded against what brand costs locally is why most people here…
does the licensed ceiling for weight differ from the diabetes one
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
✅12🔥12
how did people handle the jump from 1 to 1.7
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
im 12 months in at 1 and the appetite effect faded, is that a thing
vials not pens here
STEP 1 ran to 68 weeks. thats the one everyone half remembers
dose day is sunday for me only because thats when i remember, not because sunday matters
does moving my dose day by two days matter with a seven day half life
thats STEP 1
not the same trial
plateaus move
SELECT wasnt weight
seven days ish
for the archive im at 0.25 and stuck, did anyone break a plateau without going up
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
give it four weeks
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, from memory
same dose day
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, thats just me
genuine question the long half life flattens the trough more than people expect, i never felt a day seven dip
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
did anyone hold at 5 longer than four weeks before going up
my Medutest report on the GGPeps vial came back 96.8 against a certificate saying 99.2
i dont think the plateau is a dose problem most of the time, but i cant prove that
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
whats the actual licensed ceiling, i keep seeing different numbers
went too fast once
held there too
i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it
2.4 is the ceiling
moving my dose day by a day or two never did anything noticeable for me, n of 1 obviously
my 30 vial in 1.5ml gives 4mg/ml so 5 lands on 25 units, thats why i picked that volume
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
brand vs compounded, is there a difference people can actually feel
🧊7
the plateau hit me at 16 weeks and moved again about a month later without a dose change
compounded and brand felt the same to me at 2.4, which is one person and nothing more
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
Recon calculator: 5mg in 0.5ml = 4mg/ml.
i held at 0.25 for 4 months and it was the best decision i made, for what its worth
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, your mileage will differ
anyone compared their 4 vial dosing against the pen increments
five week steps worked better for me than four, purely on how the second week felt
follow up back after 20 months off, do i restart at 0.25 or somewhere higher