genuine question is 2.4 the top or do people go past it
#semaglutide 2025-12-23
Tuesday38 messages8 participantstimes are UTC
Highlights from this day
update on the earlier thing i held at 7.5 for 3 months and it was the best decision i made, thats one data point
right so i stayed on 1.7 for 19 months and never went to 2.4, appetite was already where i needed it
does anyone actually run a five week step instead of four
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did the STEP 4 withdrawal arm show what i think it showed
moving my dose day by a day or two never did anything noticeable for me, ill dig out the number
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
not the same trial
thats STEP 1
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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genuine question five week steps worked better for me than four, purely on how the second week felt, happy to be corrected
*VendorInvestigate not the other one
dose day is sunday for me only because thats when i remember, not because sunday matters
does the licensed ceiling for weight differ from the diabetes one
[edited]plateaus move
same dose day
anyone gone from 10 straight to 0.5 or is that too big a jump
lost about 17kg on the low doses before i even got to 1, which surprised me, from memory
mine faded too
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, we shall see
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compounded and brand felt the same to me at 1, which is one person and nothing more
ok so SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
the plateau hit me at 26 weeks and moved again about a month later without a dose change
held there too
coa-b-0114.pdf
1 page · 751 KB · not retained in the public archive
how many weeks before you noticed anything at 2.4
my PeptideMeter report on the MKM vial came back 96.8 against a certificate saying 99.2
i dont think the plateau is a dose problem most of the time, but i cant prove that
vials not pens here
vial units and pen clicks are different systems, mixing the two is how people end up wrong
brand vs compounded, is there a difference people can actually feel
2.4 is the ceiling
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ok so is the plateau at 4 weeks normal or am i doing something wrong
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
i stayed on 1.7 for 20 months and never went to 2.4, appetite was already where i needed it
SELECT wasnt weight
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11 months at 2.4 and the honest summary is diminishing returns after the first half, thats just me
compounded and brand felt the same to me at 15, which is one person and nothing more
im 17 months in at 15 and the appetite effect faded, is that a thing
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
was SELECT the one that ran to 68 weeks or am i mixing them up
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