does the licensed ceiling for weight differ from the diabetes one
#semaglutide 2025-12-11
Thursday37 messages11 participantstimes are UTC
Highlights from this day
- chaser_chris — quick one $240 a month for compounded against what brand costs locally is why most people here use vials 17:20
- vial_ledger — held at 2.5 and lost 64lb over 19 months, slower than the trials and fine by me 18:07
- two_four_ceiling — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 18:16
STEP is several trials, so saying STEP said x is usually wrong without a number after it
my VendorInvestigate report on the WWB vial came back 99.2 against a certificate saying 99.4
how long till steady state, ive read the half life is about a week
mine faded too
same dose day
is the plateau at 7 weeks normal or am i doing something wrong
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ok so i held at 2.4 for 7 months and it was the best decision i made
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
2.4 is the ceiling
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
held there too
quick one $240 a month for compounded against what brand costs locally is why most people here use vials
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dose day is sunday for me only because thats when i remember, not because sunday matters
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it
right so half life is about a week so youre roughly four to five weeks to steady state on any new dose
update on the earlier thing was STEP 1 the one that ran to 68 weeks or am i mixing them up
sorry to jump in the long half life flattens the trough more than people expect, i never felt a day seven dip
how many weeks before you noticed anything at 0.5
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vials not pens here
ok so the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
the appetite effect faded for me around 5 months and going up fixed it for a while, still working it out
sorry to jump in went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, someone check my working
held at 2.5 and lost 64lb over 19 months, slower than the trials and fine by me
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sorry to jump in whats the actual licensed ceiling, i keep seeing different numbers
give it four weeks
restarted after 9 months off at a low dose and the nausea arrived exactly like the first time
back after 19 months off, do i restart at 0.25 or somewhere higher
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
ok so does moving my dose day by two days matter with a seven day half life
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brand vs compounded, is there a difference people can actually feel
i dont think the plateau is a dose problem most of the time, but i cant prove that
genuine question my dose day drifted from friday to sunday, does that reset anything
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, take that with a pinch of salt
steady state takes weeks
12 months at 2.4 and the honest summary is diminishing returns after the first half