seven days ish
#semaglutide 2025-12-08
Monday30 messages8 participantstimes are UTC
Highlights from this day
- acetate_ash — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 18:31
- tarpit_tam — 8 months at 2.4 and the honest summary is diminishing returns after the first half 19:21
- acetate_ash — $94 a month for compounded against what brand costs locally is why most people here use vials STEP is several trials, so saying STEP said x is usually wrong without a… 19:24
- orfor_watch — does the licensed ceiling for weight differ from the diabetes one 19:28
is there a reason to hold at 1.7 rather than going to 2.4
anyone gone from 2.4 straight to 10 or is that too big a jump
held at 2.5 and lost 85lb over 21 months, slower than the trials and fine by me
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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whats the actual licensed ceiling, i keep seeing different numbers
sorry to jump in going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
[edited]the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
did anyone titrate slower than four weeks a step and how did that go
is the plateau usually appetite coming back or just the scale stopping
8 months at 2.4 and the honest summary is diminishing returns after the first half
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
not the same trial
$94 a month for compounded against what brand costs locally is why most people here use vials
STEP is several trials, so saying STEP said x is usually wrong without a number after it
compounded and brand felt the same to me at 0.5, which is one person and nothing more
2.4 is the ceiling
does the licensed ceiling for weight differ from the diabetes one
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slightly off topic but vial units and pen clicks are different systems, mixing the two is how people end up wrong
give it four weeks
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*week 29 not week 5
did the STEP 4 withdrawal arm show what i think it showed
how did people handle the jump from 1 to 1.7
is the plateau at 13 weeks normal or am i doing something wrong
SELECT wasnt weight
does the seven day half life mean the last two days are weaker
back after 11 months off, do i restart at 0.25 or somewhere higher
held there too
the appetite effect faded for me around 2 months and going up fixed it for a while