for the archive the appetite effect faded for me around 11 months and going up fixed it for a while
#semaglutide 2025-11-21
Friday48 messages10 participantstimes are UTC
Highlights from this day
- lot_number_lou — held at 1.7 and lost 39lb over 16 months, slower than the trials and fine by me 14:07
- impersonator_ip — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 15:11
- back_from_away — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 21:38
held at 1.7 and lost 39lb over 16 months, slower than the trials and fine by me
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anyone compared their 2.5 vial dosing against the pen increments
i stayed on 1.7 for 20 months and never went to 2.4, appetite was already where i needed it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
11 months at 2.4 and the honest summary is diminishing returns after the first half, i think
the plateau hit me at 18 weeks and moved again about a month later without a dose change
unrelated but vial units and pen clicks are different systems, mixing the two is how people end up wrong, take that with a pinch of salt
im at 7.5 and stuck, did anyone break a plateau without going up
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is there a reason to hold at 1.7 rather than going to 2.4
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
whats the actual licensed ceiling, i keep seeing different numbers
went too fast once
Channel stats, last 30 days: 19 messages from 28 members.
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
lost about 20kg on the low doses before i even got to 1, which surprised me
not the same trial
i dont think the plateau is a dose problem most of the time, but i cant prove that
is the plateau usually appetite coming back or just the scale stopping
same dose day
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i held at 0.25 for 8 months and it was the best decision i made, i think
half life is about a week so youre roughly four to five weeks to steady state on any new dose
compounded and brand felt the same to me at 2, which is one person and nothing more
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follow up my PeptideMeter report on the JEEP vial came back 99.2 against a certificate saying 98.6
five week steps worked better for me than four, purely on how the second week felt
£185 a month for compounded against what brand costs locally is why most people here use vials
steady state takes weeks
what did SELECT actually measure, i see it quoted for everything
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
held there too
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, take that with a pinch of salt
SELECT wasnt weight
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
vials not pens here
[edited]is the plateau at 13 weeks normal or am i doing something wrong
does the seven day half life mean the last two days are weaker
STEP 1 ran to 68 weeks. thats the one everyone half remembers
my dose day drifted from friday to sunday, does that reset anything
quick one back after 11 months off, do i restart at 0.25 or somewhere higher
does anyone actually run a five week step instead of four
seven days ish
dose day is sunday for me only because thats when i remember, not because sunday matters
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
how many weeks before you noticed anything at 2
restarted after 10 months off at a low dose and the nausea arrived exactly like the first time
plateaus move
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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