changed my mind on the four week rule, i think it depends entirely on how the current dose feels
#semaglutide 2025-11-08
Saturday59 messages11 participantstimes are UTC
Highlights from this day
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
whats the actual licensed ceiling, i keep seeing different numbers
the long half life flattens the trough more than people expect, i never felt a day seven dip
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg*PeptideMeter not the other one
is the plateau usually appetite coming back or just the scale stopping
did anybody find a difference between GGPeps and pharmacy at the same 2
went too fast once
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
im 4 months in at 0.25 and the appetite effect faded, is that a thing
did anyone hold at 15 longer than four weeks before going up
vials not pens here
👀1
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
[edited]mine faded too
🎉16👀2
give it four weeks
🔥11🧊11
half life is about a week so youre roughly four to five weeks to steady state on any new dose
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
plateaus move
14 months at 2.4 and the honest summary is diminishing returns after the first half
did the STEP 4 withdrawal arm show what i think it showed
genuine question is 2.4 the top or do people go past it
brand vs compounded, is there a difference people can actually feel
i stayed on 1.7 for 15 months and never went to 2.4, appetite was already where i needed it, i could be wrong
how long till steady state, ive read the half life is about a week
i held at 1.7 for 9 months and it was the best decision i made
my VendorInvestigate report on the SSA vial came back 99 against a certificate saying 98.1
the appetite effect faded for me around 2 months and going up fixed it for a while, not advice obviously
📉1😂1🤝1
for the archive the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
my 30 vial in 1ml gives 2.5mg/ml so 7.5 lands on 10 units, thats why i picked that volume
i held at 12 for 4 months and it was the best decision i made
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
SELECT wasnt weight
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
🙏12
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
five week steps worked better for me than four, purely on how the second week felt
compounded and brand felt the same to me at 10, which is one person and nothing more
[edited]same dose day
STEP 1 ran to 68 weeks. thats the one everyone half remembers
😂1🤝4
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, still working it out
[edited]dose day is sunday for me only because thats when i remember, not because sunday matters
does the seven day half life mean the last two days are weaker
quick one STEP is several trials, so saying STEP said x is usually wrong without a number after it
vial units and pen clicks are different systems, mixing the two is how people end up wrong
how did people handle the jump from 1 to 1.7
🎉7💀1👍6
slower worked better
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
held there too
2.4 is the ceiling
anyone gone from 1 straight to 0.25 or is that too big a jump
🔥1
thats STEP 1
anyone compared their 4 vial dosing against the pen increments
the plateau hit me at 6 weeks and moved again about a month later without a dose change
i dont think the plateau is a dose problem most of the time, but i cant prove that
declared_valueSELECT was cardiovascular outcomes in people with overweight and existing disease, not…
is there a reason to hold at 1.7 rather than going to 2.4
not the same trial
15 months at 2.4 and the honest summary is diminishing returns after the first half
moving my dose day by a day or two never did anything noticeable for me
steady state takes weeks