does anyone actually run a five week step instead of four
#semaglutide 2025-10-17
Friday51 messages12 participantstimes are UTC
Highlights from this day
plateaus move
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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dose day is sunday for me only because thats when i remember, not because sunday matters
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i dont think the plateau is a dose problem most of the time, but i cant prove that, i have it written down somewhere
the plateau hit me at 5 weeks and moved again about a month later without a dose change
held there too
*Janoshik not the other one
2.4 is the ceiling
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ok so i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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five week steps worked better for me than four, purely on how the second week felt
vials not pens here
what did SELECT actually measure, i see it quoted for everything
half life is about a week so youre roughly four to five weeks to steady state on any new dose, thats one data point
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
whats the actual licensed ceiling, i keep seeing different numbers
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compounded and brand felt the same to me at 12, which is one person and nothing more
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
moving my dose day by a day or two never did anything noticeable for me
25 months at 2.4 and the honest summary is diminishing returns after the first half
€185 a month for compounded against what brand costs locally is why most people here use vials
im 25 months in at 2.4 and the appetite effect faded, is that a thing
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held at 1 and lost 81lb over 19 months, slower than the trials and fine by me
thats STEP 1
seven days ish
right so the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
went too fast once
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
not the same trial
SELECT wasnt weight
steady state takes weeks
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my PeptideMeter report on the QST vial came back 99.2 against a certificate saying 97.4
is 2.4 the top or do people go past it
mine faded too
give it four weeks
STEP 1 ran to 68 weeks. thats the one everyone half remembers
did anyone titrate slower than four weeks a step and how did that go
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
did anybody find a difference between TFC and pharmacy at the same 2
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the appetite effect faded for me around 23 months and going up fixed it for a while
is the plateau at 14 weeks normal or am i doing something wrong
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i held at 2.4 for 6 months and it was the best decision i made
update on the earlier thing changed my mind on the four week rule, i think it depends entirely on how the current dose feels
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, we shall see
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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same dose day
slower worked better, n of 1 obviously
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing