restarted after 24 months off at a low dose and the nausea arrived exactly like the first time
#semaglutide 2025-10-03
Friday39 messages9 participantstimes are UTC
Highlights from this day
- VialBot — New independent result logged — Homopeptide, lot KP-0925, purity 98.1% (PeptideMeter). 17:10
- comment_fatigue — how long till steady state, ive read the half life is about a week 17:48
- comment_fatigue — lost about 31kg on the low doses before i even got to 1, which surprised me 17:57
- meniscus_mel — held at 2 and lost 86lb over 10 months, slower than the trials and fine by me 18:39
New independent result logged — Homopeptide, lot KP-0925, purity 98.1% (PeptideMeter).
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same dose day
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is the plateau at 21 weeks normal or am i doing something wrong
five week steps worked better for me than four, purely on how the second week felt
is 2.4 the top or do people go past it
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steady state takes weeks
2.4 is the ceiling
half life is about a week so youre roughly four to five weeks to steady state on any new dose
the appetite effect faded for me around 1 months and going up fixed it for a while
fridge-thermometer.png
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vials not pens here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
how long till steady state, ive read the half life is about a week
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lost about 31kg on the low doses before i even got to 1, which surprised me
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mine faded too
genuine question licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
seven days ish
slower worked better
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sorry to jump in moving my dose day by a day or two never did anything noticeable for me
for the archive going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
held at 2 and lost 86lb over 10 months, slower than the trials and fine by me
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
plateaus move
compounded and brand felt the same to me at 0.5, which is one person and nothing more
SELECT wasnt weight
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
dose day is sunday for me only because thats when i remember, not because sunday matters
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
i held at 0.25 for 2 months and it was the best decision i made
did anyone hold at 0.5 longer than four weeks before going up
give it four weeks
went too fast once
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thats STEP 1
while im here is the plateau usually appetite coming back or just the scale stopping
15 months at 2.4 and the honest summary is diminishing returns after the first half
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does the licensed ceiling for weight differ from the diabetes one
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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anyone compared their 4 vial dosing against the pen increments
not the same trial
what did SELECT actually measure, i see it quoted for everything
compounded and brand felt the same to me at 0.5, which is one person and nothing more