vial units and pen clicks are different systems, mixing the two is how people end up wrong
#semaglutide 2025-09-07
Sunday66 messages14 participantstimes are UTC
Highlights from this day
- VialBot — Verification log updated: WWB — evidence added, status unchanged. 10:22
- courier_vs_post — back after 6 months off, do i restart at 0.25 or somewhere higher 10:37
- acetate_ash — five week steps worked better for me than four, purely on how the second week felt 13:09
- tare_weight — does moving my dose day by two days matter with a seven day half life 13:24
slower worked better
went too fast once
how did people handle the jump from 1 to 1.7
how long did the first 29kg take for people at the low doses
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
2.4 is the ceiling
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Reminder set. I will post here in 9 days.
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
give it four weeks
what did SELECT actually measure, i see it quoted for everything
Verification log updated: WWB — evidence added, status unchanged.
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back after 6 months off, do i restart at 0.25 or somewhere higher
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
half life is about a week so youre roughly four to five weeks to steady state on any new dose
held at 7.5 and lost 75lb over 25 months, slower than the trials and fine by me
SELECT wasnt weight
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update on the earlier thing the long half life flattens the trough more than people expect, i never felt a day seven dip
held there too
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not the same trial
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
plateaus move
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mghow many weeks before you noticed anything at 10
my 2 vial in 2.5ml gives 5mg/ml so 12 lands on 40 units, thats why i picked that volume
seven days ish
compounded and brand felt the same to me at 0.25, which is one person and nothing more, i think
the appetite effect faded for me around 9 months and going up fixed it for a while
New independent result logged — GGPeps, lot SG-1177, purity 99% (Medutest).
coming back to this did anyone hold at 2 longer than four weeks before going up
vials not pens here
steady state takes weeks
anyone gone from 7.5 straight to 2.4 or is that too big a jump
coa-b-0329.pdf
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
did anybody find a difference between CPC and pharmacy at the same 1.7
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five week steps worked better for me than four, purely on how the second week felt
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
dose day is sunday for me only because thats when i remember, not because sunday matters
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moving my dose day by a day or two never did anything noticeable for me
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anyone compared their 5 vial dosing against the pen increments
vial-a-2601-front.png
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does moving my dose day by two days matter with a seven day half life
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
im at 1.7 and stuck, did anyone break a plateau without going up
the plateau hit me at 34 weeks and moved again about a month later without a dose change
my 5 vial in 5ml gives 8mg/ml so 12 lands on 20 units, thats why i picked that volume
mine faded too
quick one went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
thats STEP 1
does the licensed ceiling for weight differ from the diabetes one
i held at 2 for 2 months and it was the best decision i made
22 months at 2.4 and the honest summary is diminishing returns after the first half, i have it written down somewhere
restarted after 11 months off at a low dose and the nausea arrived exactly like the first time
did anyone titrate slower than four weeks a step and how did that go
for the archive licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
is the plateau usually appetite coming back or just the scale stopping
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brand vs compounded, is there a difference people can actually feel
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, i have it written down somewhere
im 18 months in at 5 and the appetite effect faded, is that a thing
STEP is several trials, so saying STEP said x is usually wrong without a number after it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
€185 a month for compounded against what brand costs locally is why most people here use vials
whats the actual licensed ceiling, i keep seeing different numbers
thats STEP 1, someone check my working
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, n of 1 obviously
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
my VendorInvestigate report on the MKM vial came back 99 against a certificate saying 97.4
how long till steady state, ive read the half life is about a week
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not the same trial