#semaglutide 2025-08-30

does anyone actually run a five week step instead of four

the appetite effect faded for me around 12 months and going up fixed it for a while

went too fast once

did anyone hold at 15 longer than four weeks before going up

2.4 is the ceiling

im 18 months in at 15 and the appetite effect faded, is that a thing

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

my 2 vial in 3ml gives 2mg/ml so 2 lands on 25 units, thats why i picked that volume, ill dig out the number

Assay note: QYB lot B-0114 reported at 98.1% of label content.

compounded and brand felt the same to me at 2, which is one person and nothing more

STEP is several trials, so saying STEP said x is usually wrong without a number after it

STEP 1 ran to 68 weeks. thats the one everyone half remembers

Purity check: no report on file for lot KP-0925. Nothing logged either way.

slower worked better

i dont think the plateau is a dose problem most of the time, but i cant prove that

while im here FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

moving my dose day by a day or two never did anything noticeable for me

my dose day drifted from friday to sunday, does that reset anything

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

anyone gone from 2.4 straight to 5 or is that too big a jump

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

i stayed on 1.7 for 20 months and never went to 2.4, appetite was already where i needed it

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step

half life is about a week so youre roughly four to five weeks to steady state on any new dose

is 2.4 the top or do people go past it

held there too

not the same trial

seven days ish

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, from memory

vial units and pen clicks are different systems, mixing the two is how people end up wrong

update on the earlier thing how long till steady state, ive read the half life is about a week

how did people handle the jump from 1 to 1.7

what did SELECT actually measure, i see it quoted for everything
3 months at 2.4 and the honest summary is diminishing returns after the first half

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

how many weeks before you noticed anything at 7.5

is the plateau at 34 weeks normal or am i doing something wrong

thats STEP 1

my Janoshik report on the ERP vial came back 99.4 against a certificate saying 99

im at 1.7 and stuck, did anyone break a plateau without going up

give it four weeks

is there a reason to hold at 1.7 rather than going to 2.4