#semaglutide 2025-08-26

Tuesday14 messages4 participantstimes are UTC

Highlights from this day

homa_ir_hugo — brand vs compounded, is there a difference people can actually feel 20:34
dublin_dose — does anyone actually run a five week step instead of four 20:35
dublin_dose — moving my dose day by a day or two never did anything noticeable for me 22:02

steady state takes weeks

brand vs compounded, is there a difference people can actually feel

🔥11🤝14

does anyone actually run a five week step instead of four

⚠️2🙏14👍1

plateaus move

anyone compared their 2 vial dosing against the pen increments

is the plateau at 29 weeks normal or am i doing something wrong

back after 21 months off, do i restart at 0.25 or somewhere higher

right so is 2.4 the top or do people go past it

*PeptideMeter not the other one

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

🎉1

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

follow up im 12 months in at 0.25 and the appetite effect faded, is that a thing

thats STEP 1

moving my dose day by a day or two never did anything noticeable for me

Cited study

Semaglutide vs Liraglutide for Weight Loss in Adults with Overweight or Obesity (STEP 8)

JAMA · 2022

Weekly against daily, head to head.