Reminder set. I will post here in 5 days.
#semaglutide 2025-08-09
Saturday58 messages11 participantstimes are UTC
Highlights from this day
- tga_notice — $72 a month for compounded against what brand costs locally is why most people here use vials 06:24
- luerlok — i dont think the plateau is a dose problem most of the time, but i cant prove that 07:33
- half_life_hal — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 11:01
- half_life_hal — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 11:07
does moving my dose day by two days matter with a seven day half life
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did the STEP 4 withdrawal arm show what i think it showed
my 5 vial in 1ml gives 4mg/ml so 2.5 lands on 30 units, thats why i picked that volume
for the archive my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
*PeptideMeter not the other one
genuine question the long half life flattens the trough more than people expect, i never felt a day seven dip
anyone gone from 0.5 straight to 0.25 or is that too big a jump
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seven days ish
restarted after 21 months off at a low dose and the nausea arrived exactly like the first time, not advice obviously
unrelated but im 22 months in at 0.5 and the appetite effect faded, is that a thing
vials not pens here
held there too
brand vs compounded, is there a difference people can actually feel
how long till steady state, ive read the half life is about a week
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it
ok so how did people handle the jump from 1 to 1.7
half life is about a week so youre roughly four to five weeks to steady state on any new dose
quick one SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
mine faded too
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went too fast once
is there a reason to hold at 1.7 rather than going to 2.4
thats STEP 1
is the plateau at 28 weeks normal or am i doing something wrong
dose day is sunday for me only because thats when i remember, not because sunday matters
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$72 a month for compounded against what brand costs locally is why most people here use vials
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2.4 is the ceiling
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
whats the actual licensed ceiling, i keep seeing different numbers
€120 a month for compounded against what brand costs locally is why most people here use vials
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
did anybody find a difference between HJ and pharmacy at the same 7.5
the plateau hit me at 3 weeks and moved again about a month later without a dose change
[edited]if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
coming back to this STEP 1 ran to 68 weeks. thats the one everyone half remembers
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
Reminder set. I will post here in 9 days.
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
was STEP 4 the one that ran to 68 weeks or am i mixing them up
plateaus move
anyone compared their 2.5 vial dosing against the pen increments
i held at 2 for 8 months and it was the best decision i made
did anyone titrate slower than four weeks a step and how did that go
does the seven day half life mean the last two days are weaker
i dont think the plateau is a dose problem most of the time, but i cant prove that
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how many weeks before you noticed anything at 2
im at 1 and stuck, did anyone break a plateau without going up
give it four weeks
is 2.4 the top or do people go past it
steady state takes weeks
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
not the same trial
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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lost about 44kg on the low doses before i even got to 1, which surprised me, take that with a pinch of salt
half life is about a week so youre roughly four to five weeks to steady state on any new dose, not advice obviously
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
held at 1 and lost 86lb over 2 months, slower than the trials and fine by me
SELECT wasnt weight