plateaus move
#semaglutide 2025-08-07
Thursday28 messages9 participantstimes are UTC
Highlights from this day
- sulphur_burp — while im here the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 15:11
- sulphur_burp — did anyone hold at 0.5 longer than four weeks before going up 16:09
- cross_border_cam — update on the earlier thing changed my mind on the four week rule, i think it depends entirely on how the current dose feels 16:53
- VialBot — Purity check: no report on file for lot G-0641. Nothing logged either way. 17:46
- VialBot — Inter-lab diff for lot B-0329: 97.4% vs 98.6%. Within expected range. 19:04
anyone gone from 2.4 straight to 1 or is that too big a jump
for the archive does the licensed ceiling for weight differ from the diabetes one
while im here the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
vials not pens here
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
did anyone hold at 0.5 longer than four weeks before going up
⚠️12📈3
steady state takes weeks
2.4 is the ceiling
how long till steady state, ive read the half life is about a week
update on the earlier thing changed my mind on the four week rule, i think it depends entirely on how the current dose feels
👀4⚠️8🧪15
slower worked better
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went too fast once
the long half life flattens the trough more than people expect, i never felt a day seven dip
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
Purity check: no report on file for lot G-0641. Nothing logged either way.
🎉2
moving my dose day by a day or two never did anything noticeable for me
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
thats STEP 1
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg⚠️8
Inter-lab diff for lot B-0329: 97.4% vs 98.6%. Within expected range.
🤝1😂11
is 2.4 the top or do people go past it
for the archive dose day is sunday for me only because thats when i remember, not because sunday matters
STEP 1 ran to 68 weeks. thats the one everyone half remembers
not the same trial
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing