#semaglutide 2025-08-01

Friday15 messages5 participantstimes are UTC

Highlights from this day

thyroid_thea — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 20:39
mg_per_ml — the plateau hit me at 26 weeks and moved again about a month later without a dose change 20:40
mg_per_ml — half life is about a week so youre roughly four to five weeks to steady state on any new dose 20:44
lot_number_lou — was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up 21:44
lot_number_lou — 20 months at 2.4 and the honest summary is diminishing returns after the first half 22:04

what did SELECT actually measure, i see it quoted for everything

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

the plateau hit me at 26 weeks and moved again about a month later without a dose change

half life is about a week so youre roughly four to five weeks to steady state on any new dose

seven days ish

mine faded too

im at 2 and stuck, did anyone break a plateau without going up

five week steps worked better for me than four, purely on how the second week felt

right so how did people handle the jump from 1 to 1.7

was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up

[edited]

🧊4📈1

anyone gone from 1.7 straight to 1 or is that too big a jump

i dont think the plateau is a dose problem most of the time, but i cant prove that

plateaus move

20 months at 2.4 and the honest summary is diminishing returns after the first half

thats STEP 1