follow up vial units and pen clicks are different systems, mixing the two is how people end up wrong
#semaglutide 2025-07-25
Friday54 messages11 participantstimes are UTC
Highlights from this day
- pharmac_pen — 25 months at 2.4 and the honest summary is diminishing returns after the first half 14:47
- VialBot — Verification log updated: CPC — evidence added, status unchanged. 15:55
- apnoea_down_two — did anyone titrate slower than four weeks a step and how did that go 16:14
- shame_and_meds — was STEP 4 the one that ran to 68 weeks or am i mixing them up 17:26
is 2.4 the top or do people go past it
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
i dont think the plateau is a dose problem most of the time, but i cant prove that
i dont think the plateau is a dose problem most of the time, but i cant prove that
moving my dose day by a day or two never did anything noticeable for me
£38 a month for compounded against what brand costs locally is why most people here use vials
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
held there too
slower worked better
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
[edited]not the same trial
the plateau hit me at 20 weeks and moved again about a month later without a dose change
slightly off topic but im 3 months in at 7.5 and the appetite effect faded, is that a thing
is the plateau usually appetite coming back or just the scale stopping
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
25 months at 2.4 and the honest summary is diminishing returns after the first half
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same dose day
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
whats the actual licensed ceiling, i keep seeing different numbers
im at 1.7 and stuck, did anyone break a plateau without going up
thats STEP 1
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STEP 1 ran to 68 weeks. thats the one everyone half remembers, thats one data point
vials not pens here
Verification log updated: CPC — evidence added, status unchanged.
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Verification log updated: MKM — evidence added, status unchanged.
did anyone titrate slower than four weeks a step and how did that go
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seven days ish
plateaus move
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
half life is about a week so youre roughly four to five weeks to steady state on any new dose
2.4 is the ceiling
Reminder set. I will post here in 4 days.
mine faded too
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
genuine question what did SELECT actually measure, i see it quoted for everything
was STEP 4 the one that ran to 68 weeks or am i mixing them up
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went too fast once
SELECT wasnt weight
medutest-report-e-2205.pdf
3 pages · 792 KB · not retained in the public archive
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genuine question did the STEP 4 withdrawal arm show what i think it showed
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
does the licensed ceiling for weight differ from the diabetes one
i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it
my PeptideMeter report on the SGN vial came back 98.1 against a certificate saying 97.4
does the seven day half life mean the last two days are weaker
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
steady state takes weeks
back after 17 months off, do i restart at 0.25 or somewhere higher
quick one does moving my dose day by two days matter with a seven day half life
how did people handle the jump from 1 to 1.7
dose day is sunday for me only because thats when i remember, not because sunday matters, ymmv
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
is the plateau at 7 weeks normal or am i doing something wrong
[edited]my dose day drifted from friday to sunday, does that reset anything
held at 0.25 and lost 82lb over 22 months, slower than the trials and fine by me, your mileage will differ
janoshik-h-2814.pdf
2 pages · 887 KB · not retained in the public archive
give it four weeks