seven days ish
#semaglutide 2025-07-14
Monday49 messages10 participantstimes are UTC
Highlights from this day
- pinch_not_stretch — does the seven day half life mean the last two days are weaker FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 14:10
- vienna_vial — half life is about a week so youre roughly four to five weeks to steady state on any new dose 15:34
- vienna_vial — lost about 38kg on the low doses before i even got to 1, which surprised me 15:56
- step_one_sian — how did people handle the jump from 1 to 1.7 17:04
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the plateau hit me at 5 weeks and moved again about a month later without a dose change
does the licensed ceiling for weight differ from the diabetes one
my PeptideMeter report on the QSC vial came back 98.1 against a certificate saying 99.2
slightly off topic but im 14 months in at 10 and the appetite effect faded, is that a thing
does the seven day half life mean the last two days are weaker
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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the long half life flattens the trough more than people expect, i never felt a day seven dip
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
*Medutest not the other one
not the same trial
is the plateau usually appetite coming back or just the scale stopping
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mine faded too
SELECT wasnt weight
five week steps worked better for me than four, purely on how the second week felt
does moving my dose day by two days matter with a seven day half life
what did SELECT actually measure, i see it quoted for everything
whats the actual licensed ceiling, i keep seeing different numbers
was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
half life is about a week so youre roughly four to five weeks to steady state on any new dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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vials not pens here
£120 a month for compounded against what brand costs locally is why most people here use vials
lost about 38kg on the low doses before i even got to 1, which surprised me
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quick one SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
held at 2 and lost 27lb over 21 months, slower than the trials and fine by me
same dose day
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anyone compared their 2.5 vial dosing against the pen increments
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Recon calculator: 15mg in 2ml = 5mg/ml.
give it four weeks
plateaus move
genuine question STEP 1 ran to 68 weeks. thats the one everyone half remembers
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, not advice obviously
did the STEP 4 withdrawal arm show what i think it showed
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steady state takes weeks
i stayed on 1.7 for 4 months and never went to 2.4, appetite was already where i needed it
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
while im here did anyone hold at 2.5 longer than four weeks before going up
2.4 is the ceiling
[edited]how long did the first 48kg take for people at the low doses
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went too fast once
i dont think the plateau is a dose problem most of the time, but i cant prove that
anyone gone from 1.7 straight to 12 or is that too big a jump
back after 10 months off, do i restart at 0.25 or somewhere higher
how did people handle the jump from 1 to 1.7
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how many weeks before you noticed anything at 10
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
thats STEP 1
coming back to this the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
my Medutest report on the MKM vial came back 98.1 against a certificate saying 99