going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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#semaglutide 2025-06-01
Sunday21 messages6 participantstimes are UTC
Highlights from this day
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
plateaus move
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steady state takes weeks
held there too
thats STEP 1
the appetite effect faded for me around 8 months and going up fixed it for a while
£94 a month for compounded against what brand costs locally is why most people here use vials
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the long half life flattens the trough more than people expect, i never felt a day seven dip
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
how long till steady state, ive read the half life is about a week
whats the actual licensed ceiling, i keep seeing different numbers
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
STEP is several trials, so saying STEP said x is usually wrong without a number after it, take that with a pinch of salt
is there a reason to hold at 1.7 rather than going to 2.4
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
i stayed on 1.7 for 25 months and never went to 2.4, appetite was already where i needed it
i stayed on 1.7 for 19 months and never went to 2.4, appetite was already where i needed it
moving my dose day by a day or two never did anything noticeable for me, thats one data point
brand vs compounded, is there a difference people can actually feel
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*Janoshik not the other one
five week steps worked better for me than four, purely on how the second week felt