SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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#semaglutide 2025-05-24
Saturday42 messages7 participantstimes are UTC
Highlights from this day
- third_shift — i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it 15:52
- ring_size_down — STEP is several trials, so saying STEP said x is usually wrong without a number after it 18:06
- hard_stop_hal — the plateau hit me at 15 weeks and moved again about a month later without a dose change 18:30
- hard_stop_hal — the appetite effect faded for me around 4 months and going up fixed it for a while 18:31
- ring_size_down — coming back to this back after 11 months off, do i restart at 0.25 or somewhere higher my VendorInvestigate report on the QSC vial came back 99.4 against a… 19:08
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it
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i dont think the plateau is a dose problem most of the time, but i cant prove that
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgslower worked better
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the long half life flattens the trough more than people expect, i never felt a day seven dip
my dose day drifted from friday to sunday, does that reset anything
what did SELECT actually measure, i see it quoted for everything
mine faded too
my Medutest report on the QSC vial came back 97.4 against a certificate saying 96.8
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, ymmv
*VendorInvestigate not the other one
does the seven day half life mean the last two days are weaker
is 2.4 the top or do people go past it
genuine question brand vs compounded, is there a difference people can actually feel
same dose day
did anybody find a difference between GGPeps and pharmacy at the same 15
did the STEP 4 withdrawal arm show what i think it showed
vial units and pen clicks are different systems, mixing the two is how people end up wrong
[edited]is the plateau usually appetite coming back or just the scale stopping
vials not pens here
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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dose day is sunday for me only because thats when i remember, not because sunday matters
*that should say weekly
anyone gone from 7.5 straight to 15 or is that too big a jump
give it four weeks
the plateau hit me at 15 weeks and moved again about a month later without a dose change
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the appetite effect faded for me around 4 months and going up fixed it for a while
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held there too
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
does anyone actually run a five week step instead of four
im 19 months in at 5 and the appetite effect faded, is that a thing
seven days ish
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, from memory
coming back to this back after 11 months off, do i restart at 0.25 or somewhere higher
my VendorInvestigate report on the QSC vial came back 99.4 against a certificate saying 99.2
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
how many weeks before you noticed anything at 7.5
[edited]2.4 is the ceiling
restarted after 20 months off at a low dose and the nausea arrived exactly like the first time, not advice obviously
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
for the archive my 5 vial in 2ml gives 10mg/ml so 0.5 lands on 20 units, thats why i picked that volume, for what its worth
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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