vials not pens here
#semaglutide 2025-05-03
Saturday44 messages10 participantstimes are UTC
Highlights from this day
- pbs_pip — did anyone hold at 1 longer than four weeks before going up 16:10
- no_appetite_nia — compounded and brand felt the same to me at 2, which is one person and nothing more 16:13
- pbs_pip — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, for what its worth 16:28
- no_appetite_nia — im 8 months in at 15 and the appetite effect faded, is that a thing 16:44
- VialBot — Assay note: CPC lot H-2814 reported at 99% of label content. 21:18
STEP is several trials, so saying STEP said x is usually wrong without a number after it
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
*Janoshik not the other one
plateaus move
thats STEP 1
📈10🤝10❤️1
restarted after 25 months off at a low dose and the nausea arrived exactly like the first time
STEP 1 ran to 68 weeks. thats the one everyone half remembers, thats one data point
mine faded too
five week steps worked better for me than four, purely on how the second week felt
steady state takes weeks
the plateau hit me at 28 weeks and moved again about a month later without a dose change
does anyone actually run a five week step instead of four
whats the actual licensed ceiling, i keep seeing different numbers
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, i could be wrong
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same dose day
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
anyone gone from 2 straight to 7.5 or is that too big a jump
slower worked better
€55 a month for compounded against what brand costs locally is why most people here use vials
my PeptideMeter report on the SGN vial came back 98.1 against a certificate saying 99
22 months at 2.4 and the honest summary is diminishing returns after the first half
genuine question brand vs compounded, is there a difference people can actually feel
anyone compared their 4 vial dosing against the pen increments
the appetite effect faded for me around 12 months and going up fixed it for a while
seven days ish
vial units and pen clicks are different systems, mixing the two is how people end up wrong
did anyone hold at 1 longer than four weeks before going up
moving my dose day by a day or two never did anything noticeable for me
compounded and brand felt the same to me at 2, which is one person and nothing more
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held at 12 and lost 51lb over 15 months, slower than the trials and fine by me
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, for what its worth
🙏15
is the plateau at 18 weeks normal or am i doing something wrong
16:31chlorhex pinned a message to this channel
what did SELECT actually measure, i see it quoted for everything
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
*Medutest not the other one
im 8 months in at 15 and the appetite effect faded, is that a thing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
is 2.4 the top or do people go past it
held there too
💀5❤️18📈11
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
Assay note: CPC lot H-2814 reported at 99% of label content.