i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
#semaglutide 2025-04-14
Monday39 messages11 participantstimes are UTC
Highlights from this day
- meniscus_mel — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 21:30
- point_two_five — STEP 1 ran to 68 weeks. thats the one everyone half remembers 22:28
- sharps_bin_sid — i dont think the plateau is a dose problem most of the time, but i cant prove that, someone check my working 22:30
*PeptideMeter not the other one
give it four weeks
how long did the first 37kg take for people at the low doses
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
how long till steady state, ive read the half life is about a week
held there too
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the appetite effect faded for me around 26 months and going up fixed it for a while
steady state takes weeks
my Janoshik report on the JEEP vial came back 97.4 against a certificate saying 98.6, ill dig out the number
sorry to jump in lost about 35kg on the low doses before i even got to 1, which surprised me
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
SELECT wasnt weight
same dose day
[edited]half life is about a week so youre roughly four to five weeks to steady state on any new dose
right so changed my mind on the four week rule, i think it depends entirely on how the current dose feels
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
*VendorInvestigate not the other one
plateaus move
2.4 is the ceiling
went too fast once
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgis there a reason to hold at 1.7 rather than going to 2.4
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slower worked better
dose day is sunday for me only because thats when i remember, not because sunday matters
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how did people handle the jump from 1 to 1.7
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgPurity check: no report on file for lot KP-0925. Nothing logged either way.
did the STEP 4 withdrawal arm show what i think it showed
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
seven days ish
i stayed on 1.7 for 17 months and never went to 2.4, appetite was already where i needed it
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
*that should say weekly
my dose day drifted from friday to sunday, does that reset anything
STEP 1 ran to 68 weeks. thats the one everyone half remembers
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi dont think the plateau is a dose problem most of the time, but i cant prove that, someone check my working
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did anyone hold at 0.5 longer than four weeks before going up
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
held at 12 and lost 90lb over 3 months, slower than the trials and fine by me
*VendorInvestigate not the other one