half life is about a week so youre roughly four to five weeks to steady state on any new dose
[edited]#semaglutide 2025-03-30
Sunday59 messages11 participantstimes are UTC
Highlights from this day
- chain_of_custody — anyone compared their 2 vial dosing against the pen increments 13:41
- chain_of_custody — five week steps worked better for me than four, purely on how the second week felt 14:16
- appetite_back — the appetite effect faded for me around 12 months and going up fixed it for a while 15:40
- mag_citrate — is the plateau usually appetite coming back or just the scale stopping 18:41
unrelated but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
vial units and pen clicks are different systems, mixing the two is how people end up wrong
i stayed on 1.7 for 15 months and never went to 2.4, appetite was already where i needed it
how did people handle the jump from 1 to 1.7
*PeptideMeter not the other one
my 5 vial in 2ml gives 10mg/ml so 1.7 lands on 30 units, thats why i picked that volume
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
does the seven day half life mean the last two days are weaker
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held there too
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
i dont think the plateau is a dose problem most of the time, but i cant prove that, someone check my working
seven days ish
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my Medutest report on the MKM vial came back 98.6 against a certificate saying 97.4
went too fast once
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
2.4 is the ceiling
is 2.4 the top or do people go past it
same dose day
medutest-report-b-0114.pdf
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plateaus move
Inter-lab diff for lot E-2205: 98.1% vs 99.4%. Within expected range.
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anyone compared their 2 vial dosing against the pen increments
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, i have it written down somewhere
what did SELECT actually measure, i see it quoted for everything
STEP 1 ran to 68 weeks. thats the one everyone half remembers
lot-log.csv
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five week steps worked better for me than four, purely on how the second week felt
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does anyone actually run a five week step instead of four
7 months at 2.4 and the honest summary is diminishing returns after the first half, from memory
14:37quiet.hours pinned a message to this channel
thats STEP 1
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mine faded too
lost about 41kg on the low doses before i even got to 1, which surprised me
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give it four weeks
how long did the first 15kg take for people at the low doses
SELECT wasnt weight
held at 2.4 and lost 79lb over 21 months, slower than the trials and fine by me
steady state takes weeks
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ask me again in a month
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the appetite effect faded for me around 12 months and going up fixed it for a while
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my dose day drifted from friday to sunday, does that reset anything
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
vials not pens here
how many weeks before you noticed anything at 15
not the same trial
how long till steady state, ive read the half life is about a week
im at 1 and stuck, did anyone break a plateau without going up
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i stayed on 1.7 for 3 months and never went to 2.4, appetite was already where i needed it
right so STEP is several trials, so saying STEP said x is usually wrong without a number after it
did anybody find a difference between JEEP and pharmacy at the same 2.5
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
ok so did the STEP 4 withdrawal arm show what i think it showed
dose day is sunday for me only because thats when i remember, not because sunday matters
the long half life flattens the trough more than people expect, i never felt a day seven dip
did anyone hold at 10 longer than four weeks before going up
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slower worked better
[edited]back after 25 months off, do i restart at 0.25 or somewhere higher
is the plateau usually appetite coming back or just the scale stopping
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