vialroom

#semaglutide 2025-03-18

Tuesday24 messages6 participantstimes are UTC
Highlights from this day
  • ten_of_ten — brand vs compounded, is there a difference people can actually feel 16:19
  • dorm_fridge — is 2.4 the top or do people go past it 16:47
  • evidence_or_not — how long did the first 26kg take for people at the low doses 19:47
GG

lost about 26kg on the low doses before i even got to 1, which surprised me

TO

brand vs compounded, is there a difference people can actually feel

🧊8
DF

im at 2.5 and stuck, did anyone break a plateau without going up

📈1🧊2
DF

is 2.4 the top or do people go past it

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
New England Journal of Medicine · 2021
68 weeks, semaglutide 2.4mg weekly against placebo, with lifestyle intervention in both arms.
GG

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, thats just me

CH

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, thats one data point

GG

the long half life flattens the trough more than people expect, i never felt a day seven dip

[edited]
DF

back after 16 months off, do i restart at 0.25 or somewhere higher
the plateau hit me at 11 weeks and moved again about a month later without a dose change

slower worked better

held at 10 and lost 9lb over 10 months, slower than the trials and fine by me

FT

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

EO

STEP 1 ran to 68 weeks. thats the one everyone half remembers, for what its worth

how long did the first 26kg take for people at the low doses

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, for what its worth