vialroom

#semaglutide 2025-02-23

Sunday25 messages6 participantstimes are UTC
Highlights from this day
  • freeze_thaw — my Janoshik report on the ERP vial came back 98.6 against a certificate saying 99.2 23:23
  • two_ml_two — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, ymmv 23:48
  • surpass_two — compounded and brand felt the same to me at 10, which is one person and nothing more 23:51
FA

does the licensed ceiling for weight differ from the diabetes one

what did SELECT actually measure, i see it quoted for everything

*Janoshik not the other one

vials not pens here

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

*VendorInvestigate not the other one

anyone gone from 15 straight to 7.5 or is that too big a jump

FT

12 months at 2.4 and the honest summary is diminishing returns after the first half

thats STEP 1

U1

STEP is several trials, so saying STEP said x is usually wrong without a number after it

for the archive the appetite effect faded for me around 7 months and going up fixed it for a while

FT

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

update on the earlier thing lost about 4kg on the low doses before i even got to 1, which surprised me, ask me again in a month

my Janoshik report on the ERP vial came back 98.6 against a certificate saying 99.2

😂9💀8
ST

for the archive im 20 months in at 0.25 and the appetite effect faded, is that a thing

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes (STEP 2)
The Lancet · 2021
The type 2 diabetes population, where the weight response is generally smaller.
23:28ferrous_ash pinned a message
TM

does moving my dose day by two days matter with a seven day half life

💀4⚠️1
ST

my 30 vial in 5ml gives 8mg/ml so 7.5 lands on 40 units, thats why i picked that volume

FT

how long till steady state, ive read the half life is about a week
the plateau hit me at 24 weeks and moved again about a month later without a dose change

same dose day

TM

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, ymmv

💀9🔥14👀1
ST

compounded and brand felt the same to me at 10, which is one person and nothing more

Trial scheduleWhat most people here do
Step interval4 weeks, fixed4-12 weeks, on symptoms
Holdingprotocol deviationnormal and expected
Top dosereached by designoften never reached
Coming downnot studiedcommon at maintenance
TM

dose day is sunday for me only because thats when i remember, not because sunday matters