steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
#semaglutide 2025-02-17
Monday15 messages5 participantstimes are UTC
Highlights from this day
- marrow.mod — my 10 vial in 1ml gives 8mg/ml so 15 lands on 50 units, thats why i picked that volume licensed ceiling for weight is 2.4 weekly, anything above that is not a… 18:45
- marrow.mod — ok so the long half life flattens the trough more than people expect, i never felt a day seven dip if youre comparing brand to compounded, dose accuracy in the vial… 19:09
- split_dose_sam — STEP 1 ran to 68 weeks. thats the one everyone half remembers restarted after 23 months off at a low dose and the nausea arrived exactly like the first time 20:18
- dublin_dose — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 21:02
my 10 vial in 1ml gives 8mg/ml so 15 lands on 50 units, thats why i picked that volume
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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ok so the long half life flattens the trough more than people expect, i never felt a day seven dip
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
held at 5 and lost 76lb over 1 months, slower than the trials and fine by me
2.4 is the ceiling
dose day is sunday for me only because thats when i remember, not because sunday matters
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
how long till steady state, ive read the half life is about a week
STEP 1 ran to 68 weeks. thats the one everyone half remembers
restarted after 23 months off at a low dose and the nausea arrived exactly like the first time
STEP is several trials, so saying STEP said x is usually wrong without a number after it
[edited]licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
while im here going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
held there too
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe plateau hit me at 16 weeks and moved again about a month later without a dose change