if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
#semaglutide 2025-01-31
Friday33 messages5 participantstimes are UTC
Highlights from this day
- truncation_tru — £72 a month for compounded against what brand costs locally is why most people here use vials 10:05
- reship_rita — right so i held at 0.5 for 2 months and it was the best decision i made 12:18
- blank_run — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 12:21
held there too
unrelated but does anyone actually run a five week step instead of four
not the same trial
2.4 is the ceiling
plateaus move
thats STEP 1
right so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
seven days ish
lost about 8kg on the low doses before i even got to 1, which surprised me
quick one moving my dose day by a day or two never did anything noticeable for me
14 months at 2.4 and the honest summary is diminishing returns after the first half
give it four weeks
£72 a month for compounded against what brand costs locally is why most people here use vials
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe long half life flattens the trough more than people expect, i never felt a day seven dip
STEP 1 ran to 68 weeks. thats the one everyone half remembers
half life is about a week so youre roughly four to five weeks to steady state on any new dose
transit-times.csv
491 rows · not retained in the public archive
is 2.4 the top or do people go past it
slower worked better
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
⚠️2
did anybody find a difference between Homopeptide and pharmacy at the same 0.5
restarted after 25 months off at a low dose and the nausea arrived exactly like the first time, still working it out
mine faded too
i dont think the plateau is a dose problem most of the time, but i cant prove that
i stayed on 1.7 for 5 months and never went to 2.4, appetite was already where i needed it
is there a reason to hold at 1.7 rather than going to 2.4
coming back to this dose day is sunday for me only because thats when i remember, not because sunday matters
compounded and brand felt the same to me at 7.5, which is one person and nothing more
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ymmv
right so i held at 0.5 for 2 months and it was the best decision i made
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgFLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
❤️1🎉8🔥7
how long did the first 12kg take for people at the low doses
STEP is several trials, so saying STEP said x is usually wrong without a number after it