SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
#semaglutide 2025-01-04
Saturday54 messages9 participantstimes are UTC
Highlights from this day
- thirty_one_g — dose day is sunday for me only because thats when i remember, not because sunday matters 13:32
- step_one_sian — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 16:38
- step_one_sian — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 16:54
- blank_slate_bo — restarted after 17 months off at a low dose and the nausea arrived exactly like the first time, your mileage will differ 18:51
brand vs compounded, is there a difference people can actually feel
18 months at 2.4 and the honest summary is diminishing returns after the first half
unrelated but does the seven day half life mean the last two days are weaker
went too fast once
[edited]dose day is sunday for me only because thats when i remember, not because sunday matters
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same dose day
back after 14 months off, do i restart at 0.25 or somewhere higher
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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whats the actual licensed ceiling, i keep seeing different numbers
[edited]is there a reason to hold at 1.7 rather than going to 2.4
im at 10 and stuck, did anyone break a plateau without going up
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
give it four weeks
did anyone titrate slower than four weeks a step and how did that go
the long half life flattens the trough more than people expect, i never felt a day seven dip
plateaus move
does anyone actually run a five week step instead of four
how long till steady state, ive read the half life is about a week
how did people handle the jump from 1 to 1.7
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i dont think the plateau is a dose problem most of the time, but i cant prove that
mine faded too
lost about 35kg on the low doses before i even got to 1, which surprised me, thats one data point
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slower worked better
[edited]unrelated but did anyone hold at 5 longer than four weeks before going up
steady state takes weeks
is the plateau usually appetite coming back or just the scale stopping
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the long half life flattens the trough more than people expect, i never felt a day seven dip, ask me again in a month
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
i stayed on 1.7 for 22 months and never went to 2.4, appetite was already where i needed it
anyone gone from 1.7 straight to 0.5 or is that too big a jump
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compounded and brand felt the same to me at 0.25, which is one person and nothing more
im 20 months in at 7.5 and the appetite effect faded, is that a thing
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
STEP is several trials, so saying STEP said x is usually wrong without a number after it
thats STEP 1
while im here does the licensed ceiling for weight differ from the diabetes one
thirty_one_gSTEP is several trials, so saying STEP said x is usually wrong without a number after it
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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slightly off topic but is 2.4 the top or do people go past it
did the STEP 4 withdrawal arm show what i think it showed
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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£55 a month for compounded against what brand costs locally is why most people here use vials, someone check my working
Assay note: ERP lot B-0329 reported at 99.4% of label content.
moving my dose day by a day or two never did anything noticeable for me
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, from memory
held there too
does moving my dose day by two days matter with a seven day half life
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
ok so my PeptideMeter report on the QST vial came back 97.4 against a certificate saying 99.2, ymmv
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
restarted after 17 months off at a low dose and the nausea arrived exactly like the first time, your mileage will differ
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vials not pens here
was STEP 1 the one that ran to 68 weeks or am i mixing them up
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did anybody find a difference between QST and pharmacy at the same 15