went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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#semaglutide 2024-12-20
Friday28 messages8 participantstimes are UTC
Highlights from this day
- pinch_not_stretch — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 18:24
- pinch_not_stretch — the long half life flattens the trough more than people expect, i never felt a day seven dip 18:25
- pinch_not_stretch — dose day is sunday for me only because thats when i remember, not because sunday matters, happy to be corrected STEP 1 ran to 68 weeks. thats the one everyone half… 18:29
- reta_resting_hr — compounded and brand felt the same to me at 7.5, which is one person and nothing more 19:08
- VialBot — Purity check: no report on file for lot H-2814. Nothing logged either way. 21:06
the long half life flattens the trough more than people expect, i never felt a day seven dip
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£94 a month for compounded against what brand costs locally is why most people here use vials
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dose day is sunday for me only because thats when i remember, not because sunday matters, happy to be corrected
STEP 1 ran to 68 weeks. thats the one everyone half remembers
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
plateaus move
slower worked better
the plateau hit me at 27 weeks and moved again about a month later without a dose change, i think
vials not pens here
did anyone hold at 12 longer than four weeks before going up
compounded and brand felt the same to me at 7.5, which is one person and nothing more
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give it four weeks
coming back to this SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
2.4 is the ceiling
pinch_not_stretch£94 a month for compounded against what brand costs locally is why most people here…
lost about 40kg on the low doses before i even got to 1, which surprised me
vial units and pen clicks are different systems, mixing the two is how people end up wrong
STEP 1 ran to 68 weeks. thats the one everyone half remembers
my 15 vial in 2.5ml gives 2mg/ml so 0.5 lands on 30 units, thats why i picked that volume
mine faded too
my VendorInvestigate report on the HJ vial came back 99.2 against a certificate saying 98.6
half life is about a week so youre roughly four to five weeks to steady state on any new dose
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, take that with a pinch of salt
update on the earlier thing STEP is several trials, so saying STEP said x is usually wrong without a number after it
held there too
Purity check: no report on file for lot H-2814. Nothing logged either way.
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seven days ish
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing