#semaglutide 2024-12-07

Saturday44 messages8 participantstimes are UTC

Highlights from this day

subq_sy — moving my dose day by a day or two never did anything noticeable for me, for what its worth 21:43
subq_sy — my VendorInvestigate report on the BCH vial came back 99.4 against a certificate saying 99 21:49
coa_or_cope — back after 5 months off, do i restart at 0.25 or somewhere higher 22:32

subq_sy 20:30

SELECT wasnt weight

brisbane_bac 20:34

held there too

i dont think the plateau is a dose problem most of the time, but i cant prove that, happy to be corrected

20:39ferrous_ash pinned a message to this channel

brisbane_bac 20:40

is 2.4 the top or do people go past it

subq_sy 20:41

how long did the first 19kg take for people at the low doses

thats STEP 1

brisbane_bac 20:47

steady state takes weeks

subq_sy 20:52

went too fast once

is the plateau at 24 weeks normal or am i doing something wrong

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

whats the actual licensed ceiling, i keep seeing different numbers

coa_or_cope 21:03

my 15 vial in 2.5ml gives 2mg/ml so 1.7 lands on 8 units, thats why i picked that volume

did anyone hold at 2.5 longer than four weeks before going up

coming back to this compounded and brand felt the same to me at 2.5, which is one person and nothing more, i could be wrong

spare_vial 21:11

i held at 5 for 2 months and it was the best decision i made

quick one is there a reason to hold at 1.7 rather than going to 2.4

coa_or_cope 21:15

ok so is the plateau usually appetite coming back or just the scale stopping

coa_or_cope 21:21

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

spare_vial 21:23

not the same trial

underfill_uma 21:26

what did SELECT actually measure, i see it quoted for everything

underfill_uma 21:32

the plateau hit me at 32 weeks and moved again about a month later without a dose change

underfill_uma 21:38

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

brand vs compounded, is there a difference people can actually feel

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

[edited]

subq_sy 21:42

slightly off topic but lost about 20kg on the low doses before i even got to 1, which surprised me

moving my dose day by a day or two never did anything noticeable for me, for what its worth

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

subq_sy 21:49

my VendorInvestigate report on the BCH vial came back 99.4 against a certificate saying 99

subq_sy 21:55

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

does anyone actually run a five week step instead of four

slower worked better

seven days ish

22:10ferrous_ash pinned a message to this channel

residual_solvent 22:12

dose day is sunday for me only because thats when i remember, not because sunday matters

coa_or_cope 22:15

vials not pens here

[edited]

five week steps worked better for me than four, purely on how the second week felt

coa_or_cope 22:31

give it four weeks

🧊6💀7

back after 5 months off, do i restart at 0.25 or somewhere higher

❤️7🔥2✅7

coa_or_cope 22:46

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

mine faded too

private_script_pri 22:51

restarted after 10 months off at a low dose and the nausea arrived exactly like the first time

private_script_pri 22:59

€120 a month for compounded against what brand costs locally is why most people here use vials

ferrous_ashmod23:12

did the STEP 4 withdrawal arm show what i think it showed

ferrous_ashmod23:41

follow up anyone gone from 10 straight to 5 or is that too big a jump