vialroom

#semaglutide 2024-11-07

Thursday38 messages10 participantstimes are UTC
Highlights from this day
  • VialBot — Testing queue: 9 submissions open, 39 awaiting dispatch. 18:42
  • bac_water_bill — compounded and brand felt the same to me at 12, which is one person and nothing more 19:49
  • acetate_ash — does the seven day half life mean the last two days are weaker 20:15
  • u100_pat — dose day is sunday for me only because thats when i remember, not because sunday matters 20:47
  • surpass_two — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 21:22
VB

Testing queue: 9 submissions open, 39 awaiting dispatch.

👍12
PT

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

NT

moving my dose day by a day or two never did anything noticeable for me

[edited]
NT

did anybody find a difference between GL Biochem and pharmacy at the same 12

19:07ferrous_ash pinned a message

12 months at 2.4 and the honest summary is diminishing returns after the first half, we shall see

is 2.4 the top or do people go past it

🤝2🙏3
PT

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, take that with a pinch of salt

lost about 31kg on the low doses before i even got to 1, which surprised me, not advice obviously

🧊1🧪3💀4
MP

the appetite effect faded for me around 21 months and going up fixed it for a while

BW

compounded and brand felt the same to me at 12, which is one person and nothing more

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg
NT

five week steps worked better for me than four, purely on how the second week felt

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

U1

whats the actual licensed ceiling, i keep seeing different numbers

AA

does the seven day half life mean the last two days are weaker

🙏15
AA

my 5 vial in 3ml gives 2mg/ml so 2.5 lands on 30 units, thats why i picked that volume, thats just me

1

is the plateau at 17 weeks normal or am i doing something wrong

dose day is sunday for me only because thats when i remember, not because sunday matters

📈18

i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it

medutest-report-a-2601.pdf
3 pages · 580 KB · not retained in the public archive

steady state takes weeks

ST

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.
OW

slightly off topic but the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

my Janoshik report on the KP vial came back 99 against a certificate saying 99.2, i have it written down somewhere

same dose day