Purity check: no report on file for lot F-1330. Nothing logged either way.
#semaglutide 2024-10-24
Thursday25 messages6 participantstimes are UTC
Highlights from this day
did the STEP 4 withdrawal arm show what i think it showed
[edited]lost about 16kg on the low doses before i even got to 1, which surprised me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
does anyone actually run a five week step instead of four
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vials not pens here
my 15 vial in 1.5ml gives 2.5mg/ml so 2.5 lands on 50 units, thats why i picked that volume
went too fast once
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
how did people handle the jump from 1 to 1.7
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thats STEP 1
held at 0.25 and lost 61lb over 22 months, slower than the trials and fine by me, thats one data point
follow up the appetite effect faded for me around 3 months and going up fixed it for a while
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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ok so anyone compared their 8 vial dosing against the pen increments
half life is about a week so youre roughly four to five weeks to steady state on any new dose, happy to be corrected
18 months at 2.4 and the honest summary is diminishing returns after the first half, anyway
the plateau hit me at 33 weeks and moved again about a month later without a dose change
anyone gone from 5 straight to 0.25 or is that too big a jump
held there too
how long till steady state, ive read the half life is about a week
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is there a reason to hold at 1.7 rather than going to 2.4
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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steady state takes weeks
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is the plateau at 27 weeks normal or am i doing something wrong
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SELECT wasnt weight