ok so SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
#semaglutide 2024-09-27
Friday29 messages6 participantstimes are UTC
Highlights from this day
- noct.titrate — ok so SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 21:46
- quiet.hours — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 21:58
- noct.titrate — my dose day drifted from friday to sunday, does that reset anything 22:19
- split_dose_sam — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, still working it out 22:35
- split_dose_sam — did the STEP 4 withdrawal arm show what i think it showed i stayed on 1.7 for 6 months and never went to 2.4, appetite was already where i needed it 22:46
the plateau hit me at 27 weeks and moved again about a month later without a dose change
went too fast once
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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for the archive dose day is sunday for me only because thats when i remember, not because sunday matters
im 3 months in at 0.25 and the appetite effect faded, is that a thing
slower worked better
2.4 is the ceiling
did anyone titrate slower than four weeks a step and how did that go
back after 17 months off, do i restart at 0.25 or somewhere higher
five week steps worked better for me than four, purely on how the second week felt
my dose day drifted from friday to sunday, does that reset anything
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
thats STEP 1
vial units and pen clicks are different systems, mixing the two is how people end up wrong
brand vs compounded, is there a difference people can actually feel
held at 1.7 and lost 78lb over 6 months, slower than the trials and fine by me, ill dig out the number
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, still working it out
SELECT wasnt weight
does the licensed ceiling for weight differ from the diabetes one
did the STEP 4 withdrawal arm show what i think it showed
i stayed on 1.7 for 6 months and never went to 2.4, appetite was already where i needed it
i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it
not the same trial
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vials not pens here
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
im at 0.5 and stuck, did anyone break a plateau without going up
same dose day
[edited]mine faded too