vialroom

#semaglutide 2024-06-15

Saturday43 messages10 participantstimes are UTC
Highlights from this day
  • protein_floor — vial units and pen clicks are different systems, mixing the two is how people end up wrong 15:39
  • typosquat_tay — my VendorInvestigate report on the SSA vial came back 98.6 against a certificate saying 96.8 17:26
  • protein_floor — STEP 1 ran to 68 weeks. thats the one everyone half remembers 17:51
  • noct.titrate — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 18:39
PF

lost about 37kg on the low doses before i even got to 1, which surprised me

PF

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, your mileage will differ

NT

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, n of 1 obviously

PF

follow up does the seven day half life mean the last two days are weaker
restarted after 18 months off at a low dose and the nausea arrived exactly like the first time

vial units and pen clicks are different systems, mixing the two is how people end up wrong

🧊8📈4🤝2
PF

$240 a month for compounded against what brand costs locally is why most people here use vials

update on the earlier thing brand vs compounded, is there a difference people can actually feel

PF

seven days ish

Cited study
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)
New England Journal of Medicine · 2023
Hard cardiovascular endpoints in people with overweight or obesity and established disease.
15🙏16

i stayed on 1.7 for 4 months and never went to 2.4, appetite was already where i needed it

was FLOW the one that ran to 68 weeks or am i mixing them up

3🧊4
NT

is the plateau usually appetite coming back or just the scale stopping

my 5 vial in 0.5ml gives 8mg/ml so 15 lands on 10 units, thats why i picked that volume

is 2.4 the top or do people go past it

GG

compounded and brand felt the same to me at 7.5, which is one person and nothing more

give it four weeks

GG

im 11 months in at 0.5 and the appetite effect faded, is that a thing

TT

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

TT

held at 5 and lost 33lb over 3 months, slower than the trials and fine by me
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

vials not pens here

my VendorInvestigate report on the SSA vial came back 98.6 against a certificate saying 96.8

PM

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

my dose day drifted from friday to sunday, does that reset anything

STEP 1 ran to 68 weeks. thats the one everyone half remembers

🤝1316📈14

does the licensed ceiling for weight differ from the diabetes one

GG

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

NT

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

📈11👍2

moving my dose day by a day or two never did anything noticeable for me

LM

half life is about a week so youre roughly four to five weeks to steady state on any new dose, take that with a pinch of salt

*that should say weekly

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

same dose day

vial-e-2205-front.png
900 × 1200 · 257 KB · not retained in the public archive

slower worked better

VB

Digest for the week of 2024-01-23 has been published.

NP

STEP is several trials, so saying STEP said x is usually wrong without a number after it, still working it out