lost about 30kg on the low doses before i even got to 1, which surprised me
#semaglutide 2024-03-08
Friday34 messages5 participantstimes are UTC
Highlights from this day
does the seven day half life mean the last two days are weaker
unrelated but my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
STEP is several trials, so saying STEP said x is usually wrong without a number after it
unrelated but five week steps worked better for me than four, purely on how the second week felt
what did SELECT actually measure, i see it quoted for everything
did the STEP 4 withdrawal arm show what i think it showed
did anyone titrate slower than four weeks a step and how did that go
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
is the plateau usually appetite coming back or just the scale stopping
while im here the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
give it four weeks
genuine question half life is about a week so youre roughly four to five weeks to steady state on any new dose
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, for what its worth
i dont think the plateau is a dose problem most of the time, but i cant prove that
the plateau hit me at 5 weeks and moved again about a month later without a dose change
🧊9👀1
went too fast once
the long half life flattens the trough more than people expect, i never felt a day seven dip
mine faded too
did anybody find a difference between Homopeptide and pharmacy at the same 15
steady state takes weeks
🧊16💀4📉15
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
vial units and pen clicks are different systems, mixing the two is how people end up wrong, not advice obviously
was STEP 4 the one that ran to 68 weeks or am i mixing them up
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgslower worked better
held at 1 and lost 52lb over 5 months, slower than the trials and fine by me
SELECT wasnt weight
📈7👍1🔥1
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, we shall see
does anyone actually run a five week step instead of four
STEP 1 ran to 68 weeks. thats the one everyone half remembers
restarted after 17 months off at a low dose and the nausea arrived exactly like the first time
20 months at 2.4 and the honest summary is diminishing returns after the first half
how did people handle the jump from 1 to 1.7
held there too
📈12