coming back to this how do people square the research use only framing with logging their own use
#retatrutide 2025-03-19
Wednesday35 messages7 participantstimes are UTC
Highlights from this day
- ferrous_ash — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 22:59
- ferrous_ash — stopped for 12 months and restarted at half my old dose, the ramp was easier second time, we shall see 23:33
- sarcopenia_sam — back after 13 months, has anything actually been published since 23:41
- sarcopenia_sam — while im here i log resting heart rate every morning because of this and its the one number i actually watch, thats one data point 23:46
TRIUMPH is phase 3
update on the earlier thing appetite suppression at 1 was stronger than my tirzepatide experience at a comparable point
the half life supports weekly dosing and thats what ive done from the start
watching my heart rate
anyone gone above 10 and what changed
no long term data
is the phase 2 dosing anywhere near what people here run
phase 2 only
the honest position is this has less human evidence behind it than anything else discussed here
PeptideMeter came back 99.2 on one lot and 99.4 on the next from the same MKM, both fine
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)👍1
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, we shall see
sat at 2 for 9 months rather than climbing and it kept working, so i never went up
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
quick one does the glucagon arm explain the heart rate or is that unrelated
did anyone come off because of the heart rate
my resting rate went up 9 bpm in the first month and came back most of the way by month 2
*VendorInvestigate not the other one
unrelated but TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, take that with a pinch of salt
does the energy expenditure claim show up as anything you can feel
settled by month three
the heart rate thing is real enough that i mention it whenever someone asks about starting
whats the half life like, is it weekly the same way
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
did the phase 2 result actually come in higher than the tirzepatide numbers
stopped for 12 months and restarted at half my old dose, the ramp was easier second time, we shall see
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)*Medutest not the other one
is there any long term safety data at all or is it phase 2 and hope
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
back after 13 months, has anything actually been published since
🙏3😂11
while im here i log resting heart rate every morning because of this and its the one number i actually watch, thats one data point
📉12
anyone reconstituting 2 vials to 2 so the steps come out smaller
reconstituted the 5 vial to 2mg/ml specifically so i could take 15 without measuring crumbs