triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
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#retatrutide 2025-02-27
Thursday22 messages8 participantstimes are UTC
Highlights from this day
- lipase_lore — lost 10kg over 2 months at doses well under what the trials used 23:07
- void_volume — did anyone come off because of the heart rate 23:22
- void_volume — anyone compared their Janoshik purity across two different ERP lots no idea whether the heart rate settles for everyone, mine did and one log isnt data 23:37
- void_volume — update on the earlier thing stopped for 20 months and restarted at half my old dose, the ramp was easier second time 23:41
lost 10kg over 2 months at doses well under what the trials used
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)👀13
im at 12 and the appetite effect is stronger than i expected, normal
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research use only
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the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
watching my heart rate
my resting rate went up 7 bpm in the first month and came back most of the way by month 10
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coming back to this the honest position is this has less human evidence behind it than anything else discussed here, thats one data point
sat at 5 for 3 months rather than climbing and it kept working, so i never went up, happy to be corrected
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
smaller steps here
did anyone come off because of the heart rate
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reconstituted the 30 vial to 2mg/ml specifically so i could take 15 without measuring crumbs
the heart rate thing is real enough that i mention it whenever someone asks about starting, take that with a pinch of salt
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did the phase 2 plateau or was it still moving at the end
did the phase 2 result actually come in higher than the tirzepatide numbers
anyone compared their Janoshik purity across two different ERP lots
no idea whether the heart rate settles for everyone, mine did and one log isnt data
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update on the earlier thing stopped for 20 months and restarted at half my old dose, the ramp was easier second time
[edited]baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)⚠️13👍2
back after 4 months, has anything actually been published since
TRIUMPH is phase 3
appetite suppression at 2.5 was stronger than my tirzepatide experience at a comparable point
cant feel it honestly