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#retatrutide 2025-02-15

Saturday41 messages10 participantstimes are UTC
Highlights from this day
  • salt_bridge — anyone compared their VendorInvestigate purity across two different CPC lots 15:58
  • oasis_ola — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, thats just me 16:07
  • per_mg_pete — how slow is low and slow here, four weeks a step or longer 18:02
  • triumph_watch — i said 8 months ago that my heart rate had settled and it has stayed settled since, your mileage will differ 18:07
MM

appetite suppression at 1 was stronger than my tirzepatide experience at a comparable point, someone check my working

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MM

anyone reconstituting 2 vials to 10 so the steps come out smaller
held at 1.7 for 6 months and it never plateaued for me, which i cant explain

AA

my resting heart rate is up about 8 bpm, did that settle for anyone

MM

did the phase 2 result actually come in higher than the tirzepatide numbers

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MM

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

update on the earlier thing whats a sensible starting point, im seeing everything from 0.5 to 2

SB

the heart rate thing is real enough that i mention it whenever someone asks about starting

SB

anyone compared their VendorInvestigate purity across two different CPC lots

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TRIUMPH is phase 3

OO

whats the half life like, is it weekly the same way

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is TRIUMPH the phase 3 programme

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, thats just me

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MM

reconstituted the 30 vial to 10mg/ml specifically so i could take 2.4 without measuring crumbs

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.

my resting rate went up 7 bpm in the first month and came back most of the way by month 17

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, we shall see

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the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

🎉13

did anyone come off because of the heart rate

TW

buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely

no long term data

settled by month three

VB

Purity check: no report on file for lot A-2601. Nothing logged either way.

MM

no idea whether the heart rate settles for everyone, mine did and one log isnt data

PM

i log resting heart rate every morning because of this and its the one number i actually watch

is there any long term safety data at all or is it phase 2 and hope

*VendorInvestigate not the other one

how do people square the research use only framing with logging their own use

PM

nobody should read my log as a plan, im recording what i did and thats all it is

PM

how slow is low and slow here, four weeks a step or longer

⚠️616

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule

TW

i said 8 months ago that my heart rate had settled and it has stayed settled since, your mileage will differ

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TW

GI was about the same as tirzepatide for me, the difference was how fast it arrived

TW

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan