vialroom

#retatrutide 2025-02-06

Thursday36 messages6 participantstimes are UTC
Highlights from this day
  • per_mg_pete — my resting rate went up 9 bpm in the first month and came back most of the way by month 24 17:49
  • area_percent — reconstituted the 10 vial to 2.5mg/ml specifically so i could take 10 without measuring crumbs 18:58
  • fake_tracking — phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan 20:12
FT

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

[edited]
TM

appetite suppression at 1.7 was stronger than my tirzepatide experience at a comparable point

FT

stopped for 23 months and restarted at half my old dose, the ramp was easier second time

FT

right so the honest position is this has less human evidence behind it than anything else discussed here, take that with a pinch of salt

[edited]

the half life supports weekly dosing and thats what ive done from the start

🧊14
PM

my resting rate went up 9 bpm in the first month and came back most of the way by month 24

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PM

GI was about the same as tirzepatide for me, the difference was how fast it arrived

cant feel it honestly

triple agonist meaning GLP-1, GIP and glucagon, have i got that right

AP

sorry to jump in my resting heart rate is up about 6 bpm, did that settle for anyone

smaller steps here

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reconstituted the 10 vial to 2.5mg/ml specifically so i could take 10 without measuring crumbs

🎉10📉4

triple agonist yeah

QH

ok so no idea whether the heart rate settles for everyone, mine did and one log isnt data

AP

the purity spread across lots worries me more than the molecule does

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research use only

QH

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

QH

watching my heart rate

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
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settled by month three

is there any long term safety data at all or is it phase 2 and hope

phase 2 only

people insist on small steps because the side effects arrive faster than on the other two

FT

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

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low and slow

does the glucagon arm explain the heart rate or is that unrelated

nobody should read my log as a plan, im recording what i did and thats all it is

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.