energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
#retatrutide 2025-01-28
Tuesday29 messages5 participantstimes are UTC
Highlights from this day
- split_shipment — appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point 22:13
- blind_submit — TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule 22:22
- batch_bandit — came off at 30 weeks because my resting rate stayed elevated and i didnt like it 23:03
- split_shipment — the half life supports weekly dosing and thats what ive done from the start 23:44
- VialBot — Inter-lab diff for lot C-4402: 99.2% vs 99%. Within expected range. 23:46
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
ok so lost 16kg over 16 months at doses well under what the trials used
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coming back to this reconstituted the 40 vial to 4mg/ml specifically so i could take 0.5 without measuring crumbs
appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point
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my resting rate went up 3 bpm in the first month and came back most of the way by month 23
how long before people saw the first change at 0.25
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
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right so i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
why does everyone insist on smaller steps here than on the other two
no idea whether the heart rate settles for everyone, mine did and one log isnt data, ask me again in a month
anyone reconstituting 10 vials to 10 so the steps come out smaller
the honest position is this has less human evidence behind it than anything else discussed here
settled by month three
stepping in 2 increments instead of doubling is the only thing i would change if i started again, n of 1 obviously
no long term data
anyone gone above 0.25 and what changed
held mine ages
held at 10 for 10 months and it never plateaued for me, which i cant explain
i said 6 months ago that my heart rate had settled and it has stayed settled since
*that should say weekly
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
came off at 30 weeks because my resting rate stayed elevated and i didnt like it
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)logging rhr daily
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
the purity spread across lots worries me more than the molecule does
the half life supports weekly dosing and thats what ive done from the start
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Inter-lab diff for lot C-4402: 99.2% vs 99%. Within expected range.