triple agonist meaning GLP-1, GIP and glucagon, have i got that right
stepping in 5 increments instead of doubling is the only thing i would change if i started again
#retatrutide 2024-11-25
Monday41 messages9 participantstimes are UTC
Highlights from this day
- apnoea_down_two — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me 18:05
- apnoea_down_two — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 18:35
- pharmac_pen — is TRIUMPH the phase 3 programme 19:18
- drawup_dee — i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind 19:47
the heart rate thing is real enough that i mention it whenever someone asks about starting, thats just me
phase 2 only
research use only
lost 42kg over 13 months at doses well under what the trials used
mine went up too
im at 7.5 and the appetite effect is stronger than i expected, normal
GI was about the same as tirzepatide for me, the difference was how fast it arrived
logging rhr daily
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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does the glucagon arm explain the heart rate or is that unrelated
TRIUMPH is phase 3
watching my heart rate
[edited]held mine ages
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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smaller steps here
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people insist on small steps because the side effects arrive faster than on the other two
cant feel it honestly
blood pressure stayed flat for me while heart rate moved, which i didnt expect, n of 1 obviously
for the archive did the phase 2 plateau or was it still moving at the end
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
settled by month three
apnoea_down_twoim at 7.5 and the appetite effect is stronger than i expected, normal GI was about the…
is TRIUMPH the phase 3 programme
anyone reconstituting 10 vials to 4 so the steps come out smaller
came off at 9 weeks because my resting rate stayed elevated and i didnt like it
the honest position is this has less human evidence behind it than anything else discussed here
no long term data
apnoea_down_twoblood pressure stayed flat for me while heart rate moved, which i didnt expect, n of 1…
Janoshik came back 98.1 on one lot and 99.4 on the next from the same SGN, both fine
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, take that with a pinch of salt
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
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does the energy expenditure claim show up as anything you can feel
apnoea_down_twoblood pressure stayed flat for me while heart rate moved, which i didnt expect, n of 1…
back after 6 months, has anything actually been published since
my resting rate went up 2 bpm in the first month and came back most of the way by month 8
is there any long term safety data at all or is it phase 2 and hope
how do people square the research use only framing with logging their own use
is the glucagon arm what people mean by the energy expenditure thing
my resting heart rate is up about 7 bpm, did that settle for anyone
stopped for 21 months and restarted at half my old dose, the ramp was easier second time
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
anyone gone above 10 and what changed
for the archive did the phase 2 result actually come in higher than the tirzepatide numbers
low and slow
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)