vialroom

#retatrutide 2024-11-23

Saturday31 messages10 participantstimes are UTC
Highlights from this day
  • invoice_mismatch — TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule 17:30
  • crimp_top — how do people square the research use only framing with logging their own use 18:04
  • crimp_top — why does everyone insist on smaller steps here than on the other two 18:22
  • low_and_slow — is the glucagon arm what people mean by the energy expenditure thing 20:02
MM

sorry to jump in energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

SD

GI was about the same as tirzepatide for me, the difference was how fast it arrived, still working it out

16:59marrow.mod pinned a message to this channel
SD

right so i said 4 months ago that my heart rate had settled and it has stayed settled since

MM

anyone compared their PeptideMeter purity across two different SSA lots

IM

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule

🧊14

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

cant feel it honestly

GB

blood pressure stayed flat for me while heart rate moved, which i didnt expect, thats one data point

the purity spread across lots worries me more than the molecule does

👍4

triple agonist yeah

reconstituted the 40 vial to 2.5mg/ml specifically so i could take 0.5 without measuring crumbs

[edited]

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

CT

how do people square the research use only framing with logging their own use

🔥14👍3
CT

why does everyone insist on smaller steps here than on the other two

📉10👀12

watching my heart rate

AA

buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
people insist on small steps because the side effects arrive faster than on the other two

LM

the heart rate thing is real enough that i mention it whenever someone asks about starting

💀1❤️2
TW

the half life supports weekly dosing and thats what ive done from the start

LM

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

people insist on small steps because the side effects arrive faster than on the other two

LA

is the glucagon arm what people mean by the energy expenditure thing

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
LA

came off at 23 weeks because my resting rate stayed elevated and i didnt like it

TA

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.