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#retatrutide 2024-09-05

Thursday24 messages5 participantstimes are UTC
Highlights from this day
  • bac_water_bill — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 16:57
  • taper_tess — research use only is on every vial and i treat it as exactly that, nobody here is prescribing 17:31
  • taper_tess — no idea whether the heart rate settles for everyone, mine did and one log isnt data 17:34
  • taper_tess — sat at 10 for 2 months rather than climbing and it kept working, so i never went up phase 2 doses are published and theyre not far off what people here run,… 17:35
ST

does the energy expenditure claim show up as anything you can feel

TW

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

the heart rate thing is real enough that i mention it whenever someone asks about starting
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

ST

appetite suppression at 5 was stronger than my tirzepatide experience at a comparable point

genuine question there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

TT

stepping in 1.7 increments instead of doubling is the only thing i would change if i started again, ymmv

BW

phase 2 was still trending at the end which is why the phase 3 readout matters more than usual

🙏6🔥1📉2

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

TT

for the archive did the phase 2 plateau or was it still moving at the end
i log resting heart rate every morning because of this and its the one number i actually watch

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

💀6❤️11

is the glucagon arm what people mean by the energy expenditure thing

held mine ages

no idea whether the heart rate settles for everyone, mine did and one log isnt data

📉9
ST

im at 7.5 and the appetite effect is stronger than i expected, normal

ST

sorry to jump in did the phase 2 result actually come in higher than the tirzepatide numbers