one unit is 0.01ml
#reconstitution 2025-11-04
Tuesday53 messages12 participantstimes are UTC
Highlights from this day
- nhs_pathway_nell — a slightly collapsed cake is cosmetic. a puddle in the bottom is not 15:26
- nhs_pathway_nell — if the powder is on the stopper, tap it down before you add anything. it will still dissolve either way 16:22
- appetite_back — slightly off topic but give it 8 minutes at room temperature before you decide it has not dissolved 21:09
sanity check my maths before i pin myself with something stupid
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if i add 2ml to a 2mg vial what concentration am i actually at
i have never once regretted using a rounder number and a slightly bigger volume
i swirl for about thirty seconds and then leave it. never had one fail to dissolve
one unit is 0.01ml. 100 units is 1ml. everything else in this channel follows from that
swirl it. do not shake it. the foam is denatured protein and you are not getting it back
swirl dont shake
the jewellery scale is a good habit but calibrate it, they drift badly
do i swirl for a specific length of time or just until its clear
clear or bin it
can i add more bac water later to a vial ive already reconstituted
swirl it. do not shake it. the foam is denatured protein and you are not getting it back
anyone else find the 10mg vials harder to get fully dissolved than the small ones
do you let it come to room temp before drawing or draw it cold
do you draw up with the same pin you inject with
the powder is stuck to the stopper, do i care
read it at eye level
Reminder for osaka_assay: dose day is today. Set 6 days ago.
i write the mg/ml on the vial with a sharpie the moment i reconstitute it, not advice obviously
is it normal for the cake to look slightly collapsed on one side
i use bac water even for a single-use vial because it stings less, which is not the reason it exists
my vial pulled the water in on its own, is that the vacuum or did i do something
what do you do with the last 30 units when you cant draw them cleanly
i keep a spare vial of bac water in the fridge purely so i never rush the maths
thats fine
a slightly collapsed cake is cosmetic. a puddle in the bottom is not
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if the maths gives you 13.7 units, change the volume. do not try to hit 13.7, n of 1 obviously
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anyone got a photo of what a properly dissolved vial looks like
foam is bad
you can absolutely just always use 2ml, and honestly most of us should
if the powder is on the stopper, tap it down before you add anything. it will still dissolve either way
10mg vial
+ 1.0ml -> 10.0 mg/ml 0.5mg = 5u 1mg = 10u
+ 2.0ml -> 5.0 mg/ml 0.5mg = 10u 1mg = 20u
+ 2.5ml -> 4.0 mg/ml 0.5mg = 12.5u (dont)
+ 5.0ml -> 2.0 mg/ml 0.5mg = 25u 1mg = 50u20mg in 2ml is 10mg/ml. 1mg is 10 units, 2mg is 20 units, easy
weighing the vial before you reconstitute is the only way to catch an underfill
10mg in 1ml is 10mg/ml, so 2.5mg is 25 units. thats the one i use
update from 11 months ago: switched to a single concentration and have not miscalculated since
follow up took me a year to stop over-diluting. the measurement error at 4 units is worse than the convenience
label the date too. you will not remember which vial is which by week 26
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bac water
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write the date on
does temperature of the bac water matter at all
does it matter if i inject the bac water straight at the powder
the meniscus thing is real. read it at eye level or you are guessing by a unit either way
label the vial
sorry to jump in dead space in a standard insulin syringe hub is small but it is not nothing over a month
is it worth buying a 3ml syringe for the diluent or is the insulin one fine
quick one is the meniscus reading actually a real source of error or am i overthinking
while im here my 10mg vial weighed 11.4g on the jewellery scale, is that wrong
why does everyone say 2ml specifically and not 1ml
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if you draw up with a bigger pin and inject with a fresh one you lose a bit more to dead space
follow up anyone worked out a recon volume that puts 10mg on a round unit mark
nope, redo it
slightly off topic but give it 8 minutes at room temperature before you decide it has not dissolved
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