vialroom

#reconstitution 2024-06-23

Sunday32 messages6 participantstimes are UTC
Highlights from this day
  • still_here_2024 — why does everyone say 2ml specifically and not 1ml 15:01
  • batch_bandit — give it 5 minutes at room temperature before you decide it has not dissolved, anyway 15:37
  • batch_bandit — my rule is one concentration for everything so i never have to think about it at 7am 15:41
  • tail_factor — coming back to this what do you do with the last 5 units when you cant draw them cleanly 16:15
FA

my vial pulled the water in on its own, is that the vacuum or did i do something

30mg in 3ml is 10mg/ml, so 5mg is 50 units. half the barrel, feels like a lot but its right

TF

if the maths gives you 13.7 units, change the volume. do not try to hit 13.7

why does everyone say 2ml specifically and not 1ml

🧪11

i write the mg/ml on the vial with a sharpie the moment i reconstitute it

dead space in a standard insulin syringe hub is small but it is not nothing over a month

15mg in 3ml is 5mg/ml. same numbers as 10 in 2, just more of it

clear or bin it

one unit is 0.01ml

lot-log.csv
184 rows · not retained in the public archive

not sterile water

thats the vacuum

DE

weighing the vial before you reconstitute is the only way to catch an underfill

BB

benzyl alcohol is what makes it bacteriostatic. it is about 0.9% typically

give it 5 minutes at room temperature before you decide it has not dissolved, anyway

weights-monthly.csv
621 rows · not retained in the public archive
📈18🧪8
DE

quick one the last few units are a real loss. i accept it rather than tilting the vial and drawing air

BB

my rule is one concentration for everything so i never have to think about it at 7am

🧊6🙏15

pick the volume so your dose is a whole number of units. thats the entire trick

DE

i have never once regretted using a rounder number and a slightly bigger volume, we shall see

DE

i use bac water even for a single-use vial because it stings less, which is not the reason it exists

TF

temperature of the diluent does not matter. how fast you push it in does

coming back to this what do you do with the last 5 units when you cant draw them cleanly

10mg vial
  + 1.0ml  -> 10.0 mg/ml   0.5mg =  5u   1mg = 10u
  + 2.0ml  ->  5.0 mg/ml   0.5mg = 10u   1mg = 20u
  + 2.5ml  ->  4.0 mg/ml   0.5mg = 12.5u (dont)
  + 5.0ml  ->  2.0 mg/ml   0.5mg = 25u   1mg = 50u
🔥7📈1🎉3

a 3ml syringe for the diluent and a u100 for the dose is the setup most people here end up with

weigh it first

📉14🧪1💀18

a slightly collapsed cake is cosmetic. a puddle in the bottom is not, i could be wrong