about one percent
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#oral-glp1 2025-03-02
Sunday32 messages8 participantstimes are UTC
Highlights from this day
- oasis_ola — quick one i do 6am with water and eat at 7, thats been my routine for 19 months 22:53
- oasis_ola — the fasting window is the difference between a dose and a very expensive tablet 22:58
- pharmac_pen — why is the oral dose in mg so much bigger than the injectable one 23:12
- oasis_ola — oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, for what its worth 23:22
SNAC does the work
unrelated but my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
is the plain water rule actually load bearing or is it a formality
quick one i do 6am with water and eat at 7, thats been my routine for 19 months
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On this day 6 years ago this channel logged 19 messages.
splitting a dose made the absorption problem worse rather than better in my own log
the fasting window is the difference between a dose and a very expensive tablet
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nobody should copy my morning routine, but the timer is the bit i would keep
splitting a dose made the absorption problem worse rather than better in my own log
janoshik-c-4402.pdf
2 pages · 793 KB · not retained in the public archive
coffee doesnt count
[edited]i use it because needles are a genuine problem for me, not because i think its better
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
weights-monthly.csv
483 rows · not retained in the public archive
PIONEER or OASIS, which one was the higher dose oral
coffee is not plain water. i tried it for a month and my results got worse
went back to injecting because the morning routine was too fragile around shift work
why is the oral dose in mg so much bigger than the injectable one
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ok so the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
for the archive did anyone find the oral easier on the gut than the injection
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose, take that with a pinch of salt
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, for what its worth
absorption is the variable, not the molecule. same tablet, different morning, different result, not advice obviously
coming back to this one percent is the number people quote and the spread around it is the actual story, ask me again in a month
SNAC raises the local pH and protects it long enough to cross, thats its whole job, from memory
plain water only
set a timer
technique probably
coming back to this does taking it with any food at all just waste the dose
switched from injectable to oral, lost some of the effect, switched back after 6 months
anyone switched from injectable to oral and kept the same effect
does SNAC do anything other than get it through the stomach
is the non peptide thing why orforglipron doesnt need the fasting rules