vialroom

#oral-glp1 2024-12-07

Saturday27 messages7 participantstimes are UTC
Highlights from this day
  • group_buy_gwen — unrelated but changed my mind on the plain water rule after reading how SNAC works, its not a formality 20:35
  • group_buy_gwen — the non peptide agents dose daily without the water ritual, thats the practical difference 20:36
  • thirty_one_g — the fasting window is the difference between a dose and a very expensive tablet, n of 1 obviously 21:15
  • noct.titrate — does taking it with any food at all just waste the dose 21:58
  • comment_fatigue — took 14 weeks before i saw anything on oral, roughly twice what the injection took me 23:00

is the non peptide thing why orforglipron doesnt need the fasting rules

set a timer

[edited]
Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.
DE

splitting a dose made the absorption problem worse rather than better in my own log

DE

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me

GB

unrelated but changed my mind on the plain water rule after reading how SNAC works, its not a formality

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ruined my breakfast

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absorption is the variable, not the molecule. same tablet, different morning, different result, n of 1 obviously

TO

the fasting window is the difference between a dose and a very expensive tablet, n of 1 obviously

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NT

one percent is the number people quote and the spread around it is the actual story

does taking it with any food at all just waste the dose

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TO

the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them, we shall see

CF

took 14 weeks before i saw anything on oral, roughly twice what the injection took me

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DE

went back to injecting because the morning routine was too fragile around shift work

DE

does the 30 minutes start from swallowing or from the water