vialroom

#oral-glp1 2024-06-22

Saturday24 messages7 participantstimes are UTC
Highlights from this day
  • VialBot — Digest for the week of 2024-01-01 has been published. 16:03
  • septum_sal — roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose 16:58
  • night_pin — how much water exactly, is it a small sip or half a glass 20:16
NP

did OASIS use the same fasting conditions as the earlier work

TT

splitting a dose made the absorption problem worse rather than better in my own log

VB

Digest for the week of 2024-01-01 has been published.

NP

did anyone get consistent results on the oral or is it always patchy

NP

coming back to this PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

SS

roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose

🧊15❤️16

slightly off topic but took 24 weeks before i saw anything on oral, roughly twice what the injection took me

took mine with breakfast once by accident and that week was a write off, we shall see

SS

i do 6am with water and eat at 7, thats been my routine for 20 months

LO

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted

KF

is the non peptide thing why orforglipron doesnt need the fasting rules

NP

lost 5kg over 14 months on oral, slower than my injectable stretch, i stuck with it anyway

KF

the inconsistency is mostly technique and admitting that took me about a year

NP

coffee is not plain water. i tried it for a month and my results got worse

NP

how much water exactly, is it a small sip or half a glass

[edited]
Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.