ok so my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, happy to be corrected
#dosing-titration 2026-06-04
Thursday43 messages10 participantstimes are UTC
Highlights from this day
Purity check: no report on file for lot D-0718. Nothing logged either way.
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appetite returning at the end of the week is extremely common and is not the dose failing
update on the earlier thing the ladder in the trials is a starting point, not a schedule you owe anyone
for the archive after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
is week 20 too early to be thinking about the next step
pick a day and stick to it
slightly off topic but update question: did anyone who held for 9 months regret it
the people who do best here are almost always the ones going slowest
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two weeks is nothing
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
if i took it 5 days late do i shift the schedule or go back to the old day
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came down from a treatment dose to maintenance over about three months and it was uneventful
is there any actual reason to escalate every 4 weeks other than the trial did it
*week 18 not week 7
end of week thing
anyone here split their weekly into two and would they do it again
i went from 1 to 12 and honestly could not tell the difference in appetite
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*PeptideMeter not the other one
holding is not failing. most people here who lasted two years held at least one dose for months
plateau versus set point is not answerable in under six months of data
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
for the archive i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
anyone tracked whether a smaller more frequent dose changed their side effects
hold
[edited]you do not have to escalate at all. that is a real option that gets forgotten
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thats anecdote
if i hold at 2 indefinitely am i losing anything
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)Purity check: no report on file for lot B-0114. Nothing logged either way.
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how much does the last dose still matter 8 days later
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held for months
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nobody here can tell you what dose to be on and the ones who try get corrected
too early imo
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgno trial for that
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, i think
i escalate on symptoms. if the current dose is still doing something i stay on it
On this day 7 years ago this channel logged 111 messages.
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, i could be wrong
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sorry to jump in whats the smallest step anyone has managed between doses
for the archive do you tell your prescriber you held or do you just hold
thats noise
i drifted from sunday to wednesday over a year and only noticed when i checked the log