if it "stopped working after four days" that is almost never pharmacokinetics, n of 1 obviously
#dosing-titration 2026-05-14
Thursday42 messages8 participantstimes are UTC
Highlights from this day
- alcohol_hits — do you count from injection day or from when you actually felt it 21:40
- rezept_rolf — is there a trial anywhere that studied twice weekly, or is it all anecdote 21:52
- hair_month_four — is week 27 too early to be thinking about the next step 22:23
- rezept_rolf — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 22:43
- lot_number_lou — my dose day has drifted 4 days later over 23 months, does it matter 23:21
ok so the ladder in the trials is a starting point, not a schedule you owe anyone
small steps are better than big ones and the only reason people take big ones is impatience
genuine question if you are asking whether to go up, the fact you are asking usually means not yet
whats your rule for when a side effect means hold rather than push
do you count from injection day or from when you actually felt it
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too early imo
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pick a day and stick to it
do you tell your prescriber you held or do you just hold
does a missed week reset anything or do you just carry on
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is there a trial anywhere that studied twice weekly, or is it all anecdote
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end of week thing
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
coming down from 12 to 2.4, how bad is the appetite rebound
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stepping back down on purpose is a completely reasonable move and this channel should say so more often, not advice obviously
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
n of 1
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
split dosing has no trial behind it. people here do it and report on it, thats all
i went from 10 to 15 and honestly could not tell the difference in appetite
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i drifted from sunday to wednesday over a year and only noticed when i checked the log
with a roughly seven day half-life you are near steady state after about five weeks at a dose
not advice
update from 12 months ago: held at the same dose the whole time and still losing slowly
is week 27 too early to be thinking about the next step
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came down from a treatment dose to maintenance over about three months and it was uneventful
whats the longest anyone has stayed on one dose
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, ymmv
unrelated but you do not have to escalate at all. that is a real option that gets forgotten
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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while im here my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i have been at 2.4 for 16 months and honestly i have stopped wanting to move
plateau versus set point is not answerable in under six months of data, for what its worth
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appetite returning at the end of the week is extremely common and is not the dose failing
thats noise
holding is not failing. most people here who lasted two years held at least one dose for months, i think
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
my dose day has drifted 4 days later over 23 months, does it matter
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hold
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
go slower
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, thats just me
i escalate on symptoms. if the current dose is still doing something i stay on it