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#dosing-titration 2026-04-30

Thursday34 messages7 participantstimes are UTC
Highlights from this day
  • chlorhex — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, i think 02:33
  • chlorhex — update from 19 months ago: held at the same dose the whole time and still losing slowly 02:45
  • bench_notes — the honest answer is that most of us are running protocols nobody has ever studied 02:53
  • taper_or_not — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 02:55
  • taper_or_not — how much does the last dose still matter 2 days later 03:25
HL

if you are going up because the scale stalled for two weeks, wait. two weeks is noise

i hold for two months minimum before i decide a dose has stopped doing anything

i drifted from sunday to wednesday over a year and only noticed when i checked the log

TT

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

🤝1

too early imo

⚠️4❤️1🙏9

how do you tell a plateau from just being at your set point

CH

i went from 12 to 1.7 and honestly could not tell the difference in appetite
the people who do best here are almost always the ones going slowest

LN

if you are asking whether to go up, the fact you are asking usually means not yet

TO

small steps are better than big ones and the only reason people take big ones is impatience

TO

how do you decide between holding and stepping when both feel wrong

LN

how long did you hold at 5 before you moved up
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

CH

update from 19 months ago: held at the same dose the whole time and still losing slowly

💀1⚠️163

*PeptideMeter not the other one

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

the honest answer is that most of us are running protocols nobody has ever studied

🔥4🎉10
TO

a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

🧊13📉6⚠️2

slightly off topic but came down from a treatment dose to maintenance over about three months and it was uneventful

03:22chlorhex pinned a message
TO

the trials escalated on a fixed schedule because a trial has to. you are not a trial

janoshik-b-0329.pdf
2 pages · 837 KB · not retained in the public archive
TO

split dosing has no trial behind it. people here do it and report on it, thats all

GB

if i took it 6 days late do i shift the schedule or go back to the old day

TO

follow up the ladder in the trials is a starting point, not a schedule you owe anyone

GB

if it "stopped working after four days" that is almost never pharmacokinetics